Roll Call

5-HTP — answers to 5-hydroxytryptophan

Plant

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A compound made from the amino acid tryptophan and sold as a supplement, typically derived from the seeds of Griffonia simplicifolia; it is a precursor the body uses to make serotonin.

Why it’s used

Taken to support mood and sleep.

What the evidence says

Evidence from clinical trials is limited and often methodologically weak. Some small studies suggest possible effects on mood or sleep, but results are inconsistent and larger, well-controlled trials are lacking.

Context

Studies have generally used doses in the range of a few hundred milligrams to around a gram per day over several weeks, with considerable variation in study design and quality.

Evidence: weakThe claim is made, but the evidence behind it is poor.

Educational information, not medical or safety advice. Consult a professional for allergies or medical concerns.