“Agaricus mushroom?”Here!Agaricus blazei / Agaricus subrufescens

Plant

Hasn’t appeared in a scanned product yet.

As a supplement

Talk to your doctor or pharmacist.

Roll Call does not check drug interactions or assess personal safety.

An edible mushroom species, sometimes called almond mushroom, traditionally used in parts of Brazil and Japan and now sold as a dried powder or extract in supplements.

Why it’s used

Taken by some for general immune support, a use rooted in traditional practice and marketed extract claims.

What the evidence says

Human clinical evidence is limited to small, often poorly controlled trials, mostly in cancer patients undergoing other treatment. No mainstream body has established a reliable effect from oral supplementation in healthy people.

Where we looked

There was no paper to cite here, so this is the search instead — run it yourself and see what we saw.

PubMed: 62 records · searched September 2026"Agaricus blazei"[Title/Abstract] AND (review[pt] OR "safety assessment"[Title/Abstract] OR "risk assessment"[Title/Abstract] OR toxicology[Title/Abstract] OR toxicity[Title/Abstract] OR characterization[Title/Abstract] OR characterisation[Title/Abstract])
PubMed: 4 records · searched September 2026"Agaricus blazei"[Title/Abstract] AND ("dietary supplements"[MeSH] OR supplementation[Title/Abstract] OR supplement[Title/Abstract] OR supplements[Title/Abstract] OR "oral administration"[Title/Abstract]) AND (randomized controlled trial[pt] OR clinical trial[pt] OR meta-analysis[pt] OR systematic review[pt]) AND humans[MeSH]
PubMed: 358 records · searched September 2026"Agaricus blazei"[Title/Abstract]

This says what this database holds under these terms. It is not a finding that no research exists.

Context

Available trials use inconsistent extract preparations and dosing, which limits any comparison or generalization.

Rumors

1
Agaricus blazei improves insulin resistance and helps people with diabetes.
Supports — suggestivehealth and safety evidence
Studied in: adults aged 20-75 with type 2 diabetes already on metformin and gliclazide.
Measured as a biomarker.
- The mushroom Agaricus blazei Murill in combination with metformin and gliclazide improves insulin resistance in type 2 diabetes: a randomized, double-blinded, and placebo-controlled clinical trial (Peer-reviewed) · Funding not checked
Who’s saying this
- Global Healing — a brand: sells natural vitamins, minerals, herbal supplements, skincare and detox protocols
  How we know who this is
  “Global Healing is here to guide your journey to whole-body wellness with natural vitamins, minerals, herbal supplements, skincare, and detox protocols.” (their page)
2
Agaricus blazei contains a toxic compound, agaritine.
We haven’t found evidence strong enough to support this or rule it out.
What was measured is not yet noted.
Who’s saying this
- Inspire — a platform — posts are by its users: health community paid by clinical trial sponsors for recruitment
  How we know who this is
  “Inspire is the world's largest health community.” (their page)
  “Clinical trial sponsors pay Inspire for this service.” (their page)
3
Agaricus mushroom supplements can cause severe liver damage.
Supports — suggestivehealth and safety evidence
Studied in: cancer patients taking Agaricus blazei extract as complementary/alternative medicine.
Measured as an outcome.
- An alternative medicine, Agaricus blazei, may have induced severe hepatic dysfunction in cancer patients (Peer-reviewed) · Funding not checked
- Drug-induced liver injury associated with Agaricus blazei Murill which is very similar to autoimmune hepatitis (Peer-reviewed) · Funding not checked · No conflicts declared
Who’s saying this
- RxList — a publisher: drug information resource; owned by WebMD
  How we know who this is
  “RxList is an online medical resource dedicated to offering detailed and current pharmaceutical information on brand and generic drugs.” (their page)
  “RxList.com - Owned and Operated by WebMD and part of the WebMD network.” (their page)
4
Agaricus mushroom fights cancer and helps cancer patients.
Does not supporthealth and safety evidence
Studied in: multiple myeloma patients undergoing high-dose chemotherapy and autologous stem cell transplantation.
Measured as an outcome.
- Immunomodulatory Effects of the Agaricus blazei Murrill-Based Mushroom Extract AndoSan in Patients with Multiple Myeloma Undergoing High Dose Chemotherapy and Autologous Stem Cell Transplantation: A Randomized, Double Blinded Clinical Study (Peer-reviewed) · Funded by Immunopharma AS (product and research grant); Oslo University Hospital (main laboratory analysis) (industry) · Authors declare a conflict of interest
- Antitumor, Anti-inflammatory and Antiallergic Effects of Agaricus blazei Mushroom Extract and the Related Medicinal Basidiomycetes Mushrooms, Hericium erinaceus and Grifola frondosa: A Review of Preclinical and Clinical Studies (Peer-reviewed) · Funding not clearly stated · Authors declare a conflict of interest
Who’s saying this
- AAI Rejuvenation — a brand: sells bioidentical hormone therapy and anti-aging treatments
  How we know who this is
  “AAI Rejuvenation offers hormone therapy and other anti-aging solutions that can assist you in finding a healthier, happier you.” (their page)
  “AAI Rejuvenation provides quality bioidentical hormone therapy delivered to your door.” (their page)
5
Agaricus blazei boosts the immune system by activating the body's natural defenses.
Unresolvedhealth and safety evidence
Studied in: cancer patients (multiple myeloma undergoing stem cell transplant; NSCLC post-surgery).
Measured as a biomarker.
- Immunomodulatory Effects of the Agaricus blazei Murrill-Based Mushroom Extract AndoSan in Patients with Multiple Myeloma Undergoing High Dose Chemotherapy and Autologous Stem Cell Transplantation: A Randomized, Double Blinded Clinical Study (Peer-reviewed) · Funded by Immunopharma AS (product and research grant); Oslo University Hospital (main laboratory analysis) (industry) · Authors declare a conflict of interest
- Immunomodulatory Effects of Multivitamin Complexes Containing Agaricus blazei in Patients Undergoing Curative Resection for Non-Small-Cell Lung Cancer: A Randomized, Double-Blind, Placebo-Controlled Multicenter Pilot Trial (Peer-reviewed) · Funded by NKmax Co., Ltd. (industry) · No conflicts declared
- Antitumor, Anti-inflammatory and Antiallergic Effects of Agaricus blazei Mushroom Extract and the Related Medicinal Basidiomycetes Mushrooms, Hericium erinaceus and Grifola frondosa: A Review of Preclinical and Clinical Studies (Peer-reviewed) · Funding not clearly stated · Authors declare a conflict of interest
Who’s saying this
- Global Healing — a brand: sells natural vitamins, minerals, herbal supplements, skincare and detox protocols
  How we know who this is
  “Global Healing is here to guide your journey to whole-body wellness with natural vitamins, minerals, herbal supplements, skincare, and detox protocols.” (their page)