“Agmatine?”Here!
Hasn’t appeared in a scanned product yet.
As a supplement
Talk to your doctor or pharmacist.
Roll Call does not check drug interactions or assess personal safety.
Agmatine is a compound made in the body from the amino acid arginine, and produced commercially by fermentation for use as a supplement ingredient.
Why it’s used
Taken by some who exercise, often marketed for muscle 'pump' during resistance training or as a nootropic for focus.
What the evidence says
Human trial data is sparse. A handful of small studies have looked at agmatine sulfate for exercise performance or pain, but results are inconsistent and sample sizes are small. There is no NIH Office of Dietary Supplements fact sheet on agmatine, and no settled evidence for the effects it is marketed for.
Where we looked
There was no paper to cite here, so this is the search instead — run it yourself and see what we saw.
- PubMed: 301 records · searched September 2026
"Agmatine"[Title/Abstract] AND (review[pt] OR "safety assessment"[Title/Abstract] OR "risk assessment"[Title/Abstract] OR toxicology[Title/Abstract] OR toxicity[Title/Abstract] OR characterization[Title/Abstract] OR characterisation[Title/Abstract]) - PubMed: 1 record · searched September 2026
"Agmatine"[Title/Abstract] AND ("dietary supplements"[MeSH] OR supplementation[Title/Abstract] OR supplement[Title/Abstract] OR supplements[Title/Abstract] OR "oral administration"[Title/Abstract]) AND (randomized controlled trial[pt] OR clinical trial[pt] OR meta-analysis[pt] OR systematic review[pt]) AND humans[MeSH] - PubMed: 1868 records · searched September 2026
"Agmatine"[Title/Abstract]
This says what this database holds under these terms. It is not a finding that no research exists.
Context
Where studied, trials have generally used agmatine sulfate rather than agmatine base, complicating dose comparisons across the limited literature.
Rumors
Agmatine improves mood and relieves discomfort through the body's opioid system.
We haven’t found evidence strong enough to support this or rule it out.
What was measured is not yet noted.
Who’s saying this
- Nootropics Depot — a brand: sells supplements
How we know who this is
- “Nootropics Depot is located in Tempe Arizona.” (their page)
- “While we started our journey with nootropics, we now sell many different supplements for all sorts of goals.” (their page)
- Nootropics Depot — a brand: sells supplements
Agmatine improves memory and cognitive performance and protects neurons.
We haven’t found evidence strong enough to support this or rule it out.
What was measured is not yet noted.
Who’s saying this
- Nootropics Depot — a brand: sells supplements
How we know who this is
- “Nootropics Depot is located in Tempe Arizona.” (their page)
- “While we started our journey with nootropics, we now sell many different supplements for all sorts of goals.” (their page)
- Nootropics Depot — a brand: sells supplements
Agmatine improves insulin sensitivity and glucose metabolism.
We haven’t found evidence strong enough to support this or rule it out.
What was measured is not yet noted.
Who’s saying this
- Nootropics Depot — a brand: sells supplements
How we know who this is
- “Nootropics Depot is located in Tempe Arizona.” (their page)
- “While we started our journey with nootropics, we now sell many different supplements for all sorts of goals.” (their page)
- Nootropics Depot — a brand: sells supplements
Agmatine can cause digestive upset.
We haven’t found evidence strong enough to support this or rule it out.
What was measured is not yet noted.
Who’s saying this
- Nootropics Depot — a brand: sells supplements
How we know who this is
- “Nootropics Depot is located in Tempe Arizona.” (their page)
- “While we started our journey with nootropics, we now sell many different supplements for all sorts of goals.” (their page)
- Nootropics Depot — a brand: sells supplements
Agmatine boosts blood flow and muscle pumps during workouts by acting on nitric oxide.
We haven’t found evidence strong enough to support this or rule it out.
What was measured is not yet noted.
Who’s saying this
- Nootropics Depot — a brand: sells supplements
How we know who this is
- “Nootropics Depot is located in Tempe Arizona.” (their page)
- “While we started our journey with nootropics, we now sell many different supplements for all sorts of goals.” (their page)
- Nootropics Depot — a brand: sells supplements