Agmatine
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Agmatine is a compound made in the body from the amino acid arginine, and produced commercially by fermentation for use as a supplement ingredient.
Why it’s used
Taken by some who exercise, often marketed for muscle 'pump' during resistance training or as a nootropic for focus.
What the evidence says
Human trial data is sparse. A handful of small studies have looked at agmatine sulfate for exercise performance or pain, but results are inconsistent and sample sizes are small. There is no NIH Office of Dietary Supplements fact sheet on agmatine, and no settled evidence for the effects it is marketed for.
Where we looked
There was no paper to cite here, so this is the search instead — run it yourself and see what we saw.
- PubMed: 1 record · searched August 2026
"Agmatine"[Title/Abstract] AND ("dietary supplements"[MeSH] OR supplementation[Title/Abstract] OR supplement[Title/Abstract] OR supplements[Title/Abstract] OR "oral administration"[Title/Abstract]) AND (randomized controlled trial[pt] OR clinical trial[pt] OR meta-analysis[pt] OR systematic review[pt]) AND humans[MeSH] - PubMed: 1859 records · searched August 2026
"Agmatine"[Title/Abstract]
This says what this database holds under these terms. It is not a finding that no research exists.
Context
Where studied, trials have generally used agmatine sulfate rather than agmatine base, complicating dose comparisons across the limited literature.
Educational information, not medical or safety advice. Consult a professional for allergies or medical concerns.