“Apigenin?”Here!
Hasn’t appeared in a scanned product yet.
As a supplement
Talk to your doctor or pharmacist.
Roll Call does not check drug interactions or assess personal safety.
A flavone, a type of plant pigment compound, found in chamomile flowers, parsley, celery, and other produce. Supplement versions are usually made from purified plant extract or synthesized to match the natural molecule.
Why it’s used
Taken by people hoping to support relaxation or sleep, an idea borrowed largely from chamomile's traditional use.
What the evidence says
Isolated apigenin, as a standalone supplement ingredient, has not been well studied in human trials. Most of what informs its reputation comes from chamomile tea or extract research, which is itself limited and mixed, and does not establish that concentrated apigenin alone produces the same effects.
Where we looked
There was no paper to cite here, so this is the search instead — run it yourself and see what we saw.
- PubMed: 1353 records · searched September 2026
"Apigenin"[Title/Abstract] AND (review[pt] OR "safety assessment"[Title/Abstract] OR "risk assessment"[Title/Abstract] OR toxicology[Title/Abstract] OR toxicity[Title/Abstract] OR characterization[Title/Abstract] OR characterisation[Title/Abstract]) - PubMed: 2 records · searched September 2026
"Apigenin"[Title/Abstract] AND ("dietary supplements"[MeSH] OR supplementation[Title/Abstract] OR supplement[Title/Abstract] OR supplements[Title/Abstract] OR "oral administration"[Title/Abstract]) AND (randomized controlled trial[pt] OR clinical trial[pt] OR meta-analysis[pt] OR systematic review[pt]) AND humans[MeSH] - PubMed: 7232 records · searched September 2026
"Apigenin"[Title/Abstract]
This says what this database holds under these terms. It is not a finding that no research exists.
Context
Human trials on chamomile (which contains apigenin among other compounds) have used varying extract doses and mostly measured mild anxiety or sleep-quality scores over a few weeks; findings are inconsistent and do not isolate apigenin's individual contribution.
Rumors
Apigenin supports healthy aging by boosting NAD+ metabolism and reducing oxidative stress.
Supports — suggestivehealth and safety evidence
Studied in: obese mice fed a high-fat diet (animal model).
Measured as a biomarker.
- Flavonoid Apigenin Is an Inhibitor of the NAD+ase CD38: Implications for Cellular NAD+ Metabolism, Protein Acetylation, and Treatment of Metabolic Syndrome (Peer-reviewed) · Funded by American Federation for Aging Research; Mayo Foundation; NIDDK/NIH; Minnesota Obesity Council (government) · Authors declare a conflict of interest
- Apigenin: a natural molecule at the intersection of sleep and aging (Peer-reviewed) · Funded by Tally Health, NY, USA (industry) · Authors declare a conflict of interest
Who’s saying this
- Dr. Jolene Brighten — a professional body or practice: sells her books on women's hormonal health
How we know who this is
- “Dr. Jolene Brighten is a board-certified naturopathic endocrinologist and the author of four books on women’s hormonal health, including ADHD and Women (Penguin Random House).” (their page)
Apigenin supplements help you relax and get more restorative sleep.
Sources unreachable — that's our end, not a finding.
What was measured is not yet noted.
- Apigenin: a natural molecule at the intersection of sleep and aging (Peer-reviewed) · Funded by Tally Health, NY, USA (industry) · Authors declare a conflict of interest
Who’s saying this
- Dr. Jolene Brighten — a professional body or practice: sells her books on women's hormonal health
How we know who this is
- “Dr. Jolene Brighten is a board-certified naturopathic endocrinologist and the author of four books on women’s hormonal health, including ADHD and Women (Penguin Random House).” (their page)
Apigenin supplements support prostate health and cognition in men.
Not gradedhealth and sourcing evidence
Sources cited — no verdict reached.
What was measured is not yet noted.
- Long-term Dietary Flavonoid Intake and Subjective Cognitive Decline in US Men and Women (Peer-reviewed) · Funded by National Institutes of Health (government) · No conflicts declared
- Apigenin (NGO or audit) · Funding not checked
Who’s saying this
- macys.com — we couldn’t open the site to see who runs it
Apigenin relieves anxiety and stress.
Not gradedhealth and sourcing evidence
Sources cited — no verdict reached.
What was measured is not yet noted.
- Long-term chamomile (Matricaria chamomilla L.) treatment for generalized anxiety disorder: A randomized clinical trial (Peer-reviewed) · Funded by NIH / National Center for Complementary and Integrative Health; NIH / National Cancer Institute (government) · No conflicts declared
- Apigenin (NGO or audit) · Funding not checked
Who’s saying this
- Walmart — a retailer: sells fashion, home goods and more; Walmart+ membership
How we know who this is
- “The trademarks Walmart and the Walmart Spark design are registered with the US Patent and Trademark Office.” (their page)
- “Annual members can save $380 per year!” (their page)
Apigenin is not habit-forming or addictive.
Not gradedhealth and safety evidence
Sources cited — no verdict reached.
What was measured is not yet noted.
- Long-term chamomile (Matricaria chamomilla L.) treatment for generalized anxiety disorder: A randomized clinical trial (Peer-reviewed) · Funded by NIH / National Center for Complementary and Integrative Health; NIH / National Cancer Institute (government) · No conflicts declared
Who’s saying this
- Momentous — a brand: sells its own nutrition supplements
How we know who this is
- “From everyday high performers to professional athletes, Momentous helps support health, performance, and longevity through science-backed nutrition.” (their page)
- “We founded Momentous because we believed supplements should be made better, from the ingredients we source to the way every product is formulated and tested.” (their page)