“Aspergillopepsin?”Here!
Hasn’t appeared in a scanned product yet.
As a supplement
Talk to your doctor or pharmacist.
Roll Call does not check drug interactions or assess personal safety.
A protein-digesting enzyme produced by fermentation of Aspergillus mold species, used in enzyme supplement blends.
Why it’s used
Included in digestive enzyme products intended to support the breakdown of dietary protein, sometimes marketed for activity across a range of stomach pH levels.
What the evidence says
Aspergillopepsin is well documented as an industrial and food-processing enzyme, but clinical evidence for oral supplementation improving digestion or any other outcome in healthy people is very limited, and there is no NIH ODS coverage of this ingredient.
Where we looked
There was no paper to cite here, so this is the search instead — run it yourself and see what we saw.
- PubMed: 17 records · searched September 2026
"Aspergillopepsin"[Title/Abstract] AND (review[pt] OR "safety assessment"[Title/Abstract] OR "risk assessment"[Title/Abstract] OR toxicology[Title/Abstract] OR toxicity[Title/Abstract] OR characterization[Title/Abstract] OR characterisation[Title/Abstract]) - PubMed: 0 records · searched September 2026
"Aspergillopepsin"[Title/Abstract] AND ("dietary supplements"[MeSH] OR supplementation[Title/Abstract] OR supplement[Title/Abstract] OR supplements[Title/Abstract] OR "oral administration"[Title/Abstract]) AND (randomized controlled trial[pt] OR clinical trial[pt] OR meta-analysis[pt] OR systematic review[pt]) AND humans[MeSH] - PubMed: 70 records · searched September 2026
"Aspergillopepsin"[Title/Abstract]
This says what this database holds under these terms. It is not a finding that no research exists.
Context
Available data are largely from enzymatic activity assays rather than human outcome trials.
Rumors
Aspergillopepsin digests gluten effectively.
Does not support — establishedhealth and safety evidence
What was measured is not yet noted.
- A Food-Grade Enzyme Preparation with Modest Gluten Detoxification Properties (Peer-reviewed) · Funding not checked
- Ineffective Degradation of Immunogenic Gluten Epitopes by Currently Available Digestive Enzyme Supplements (Peer-reviewed) · Funded by Celiac Disease Consortium / Netherlands Genomics Initiative and Dutch government (grant BSIK03009); DSM Food Specialties (industry) · Authors declare a conflict of interest
Who’s saying this
- Genemedics Health Institute — a professional body or practice: bioidentical hormone replacement therapy and preventive health clinic
How we know who this is
- “Genemedics Health Institute is a leading center for the best bioidentical hormone replacement therapy and preventive health.” (their page)
Aspergillopepsin aids digestion of proteins and carbohydrates.
Not gradedhealth and safety evidence
Sources cited — no verdict reached.
What was measured is not yet noted.
- A Food-Grade Enzyme Preparation with Modest Gluten Detoxification Properties (Peer-reviewed) · Funding not checked
Who’s saying this
- Genemedics Health Institute — a professional body or practice: bioidentical hormone replacement therapy and preventive health clinic
How we know who this is
- “Genemedics Health Institute is a leading center for the best bioidentical hormone replacement therapy and preventive health.” (their page)
Aspergillopepsin supplements relieve celiac disease symptoms caused by accidental gluten exposure.
Does not support — suggestivehealth and safety evidence
Studied in: celiac disease patients with persistent elevated tTG-IgA despite gluten-free diet.
Measured as a biomarker.
- Celiac Disease and Non-celiac Wheat Sensitivity: State of Art of Non-dietary Therapies (Peer-reviewed) · Funding not checked · Authors declare a conflict of interest
- Commercially available glutenases: a potential hazard in coeliac disease (Peer-reviewed) · Funding not checked · No conflicts declared
Who’s saying this
- Clinicals Health — a brand: sells digestive enzyme supplements
How we know who this is
- “Clinicals Health has formulated a powerful combination of essential digestive enzymes that are fast working and effective, to ensure you benefit from the maximum absorption of nutrient value in the foods you are eating.” (their page)
- “Take control of your digestive wellness today with our range of high-quality digestive enzymes and healthy gut supplements, your go-to digestive problems treatment.” (their page)
Aspergillopepsin lowers high cholesterol.
We haven’t found evidence strong enough to support this or rule it out.
What was measured is not yet noted.
Who’s saying this
- Clinicals Health — a brand: sells digestive enzyme supplements
How we know who this is
- “Clinicals Health has formulated a powerful combination of essential digestive enzymes that are fast working and effective, to ensure you benefit from the maximum absorption of nutrient value in the foods you are eating.” (their page)
- “Take control of your digestive wellness today with our range of high-quality digestive enzymes and healthy gut supplements, your go-to digestive problems treatment.” (their page)
- Clinicals Health — a brand: sells digestive enzyme supplements
Aspergillopepsin prevents constipation and normalizes bowel movements.
We haven’t found evidence strong enough to support this or rule it out.
What was measured is not yet noted.
Who’s saying this
- Genemedics Health Institute — a professional body or practice: bioidentical hormone replacement therapy and preventive health clinic
How we know who this is
- “Genemedics Health Institute is a leading center for the best bioidentical hormone replacement therapy and preventive health.” (their page)
- Genemedics Health Institute — a professional body or practice: bioidentical hormone replacement therapy and preventive health clinic