Benfotiamine — answers to a fat-soluble form of vitamin B1
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A synthetic, fat-soluble derivative of thiamine (vitamin B1), designed to be absorbed differently than standard thiamine salts.
Why it’s used
Taken by some to support nerve health, particularly in the context of diabetic peripheral neuropathy.
What the evidence says
Clinical trials of benfotiamine for diabetic neuropathy have produced mixed results, and a Cochrane systematic review of B vitamins (including benfotiamine) for diabetic peripheral neuropathy found the evidence insufficient to draw firm conclusions about benefit. The overall body of human trial evidence remains small and inconsistent.
Dose studied
300–600 mg — typical daily doses used in clinical trials for diabetic neuropathy.
Context
Studies have generally used doses in the range of a few hundred milligrams per day over weeks to months, but trial design and outcome measures vary considerably, and long-term data are limited.
Educational information, not medical or safety advice. Consult a professional for allergies or medical concerns.