Roll Call

“Betaine Anhydrous?”Here!trimethylglycine (TMG)

Varies by source

Hasn’t appeared in a scanned product yet.

As a supplement

Talk to your doctor or pharmacist.

Roll Call does not check drug interactions or assess personal safety.

A compound derived from the amino acid glycine, naturally found in foods such as beets, spinach, and whole grains; "anhydrous" refers to the water-free form used in supplements.

Why it’s used

Taken to support homocysteine metabolism and, in some products, exercise performance or body composition.

What the evidence is for

supporting homocysteine metabolism through the methylation cycle.

What the evidence says

Betaine has an established role in the body's methylation cycle and homocysteine metabolism. In supplement research on exercise performance, some studies report modest improvements in strength or power output while others show no effect, so this area of evidence is less settled.

Dose studied

1.5–6 g — doses used in exercise-performance and methylation-related studies.

Context

Exercise-performance studies have generally used doses of about 2.5 g/day for two to six weeks; results across trials on performance outcomes are inconsistent.

Rumors

  1. Supporting homocysteine metabolism through the methylation cycle.

    Not gradedhealth and safety evidence

    Sources cited — no verdict reached.

    What was measured is not yet noted.