Betaine Anhydrous — answers to trimethylglycine (TMG)
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A compound derived from the amino acid glycine, naturally found in foods such as beets, spinach, and whole grains; "anhydrous" refers to the water-free form used in supplements.
Why it’s used
Taken to support homocysteine metabolism and, in some products, exercise performance or body composition.
What the evidence is for
supporting homocysteine metabolism through the methylation cycle.
What the evidence says
Betaine has an established role in the body's methylation cycle and homocysteine metabolism. In supplement research on exercise performance, some studies report modest improvements in strength or power output while others show no effect, so this area of evidence is less settled.
Dose studied
1.5–6 g — doses used in exercise-performance and methylation-related studies.
Context
Exercise-performance studies have generally used doses of about 2.5 g/day for two to six weeks; results across trials on performance outcomes are inconsistent.
Educational information, not medical or safety advice. Consult a professional for allergies or medical concerns.