“Bromelain?”Here!pineapple enzyme
Hasn’t appeared in a scanned product yet.
As a supplement
Talk to your doctor or pharmacist.
Roll Call does not check drug interactions or assess personal safety.
A mixture of protein-digesting enzymes extracted from the stem and fruit of the pineapple plant.
Why it’s used
Taken to support digestion, and sometimes marketed for reducing swelling or discomfort after minor injury or surgery.
What the evidence says
Human evidence is limited. Some small trials have examined effects on swelling and pain after dental or minor surgical procedures, but study designs and doses vary widely and results have not been consolidated into a settled conclusion by major evidence reviews.
Where we looked
There was no paper to cite here, so this is the search instead — run it yourself and see what we saw.
- PubMed: 350 records · searched September 2026
"Bromelain"[Title/Abstract] AND (review[pt] OR "safety assessment"[Title/Abstract] OR "risk assessment"[Title/Abstract] OR toxicology[Title/Abstract] OR toxicity[Title/Abstract] OR characterization[Title/Abstract] OR characterisation[Title/Abstract]) - PubMed: 34 records · searched September 2026
"Bromelain"[Title/Abstract] AND ("dietary supplements"[MeSH] OR supplementation[Title/Abstract] OR supplement[Title/Abstract] OR supplements[Title/Abstract] OR "oral administration"[Title/Abstract]) AND (randomized controlled trial[pt] OR clinical trial[pt] OR meta-analysis[pt] OR systematic review[pt]) AND humans[MeSH] - PubMed: 2127 records · searched September 2026
"Bromelain"[Title/Abstract]
This says what this database holds under these terms. It is not a finding that no research exists.
Context
Studied doses and protocols vary considerably between small trials, without a consistent regimen used across the research.
Rumors
Bromelain supports cardiovascular health.
Does not support — suggestivehealth and safety evidence
Measured as an outcome.
- Efficacy and safety of bromelain: A systematic review and meta-analysis (Peer-reviewed) · Funding not checked
- Bromelain and cardiovascular risk factors in diabetes: An exploratory randomized, placebo controlled, double blind clinical trial (Peer-reviewed) · Funding not checked
- Potential health benefits of bromelain: a critical review of the current literature (Peer-reviewed) · Funding not clearly stated · No conflicts declared
Who’s saying this
- Life Extension — a brand: sells its own vitamins and supplements
How we know who this is
- “Life Extension is a privately owned vitamin and supplement company.” (their page)
Bromelain supplements help digestion and promote a healthy inflammatory response.
Not gradedhealth and safety evidence
Sources cited — no verdict reached.
What was measured is not yet noted.
- Bromelain and cardiovascular risk factors in diabetes: An exploratory randomized, placebo controlled, double blind clinical trial (Peer-reviewed) · Funding not checked
- Effects of bromelain supplementation on disease activity and quality of life in patients with ulcerative colitis: a randomized, triple-blind, placebo-controlled study (Peer-reviewed) · Funding not checked · No conflicts declared
Who’s saying this
- Life Extension — a brand: sells its own vitamins and supplements
How we know who this is
- “Life Extension is a privately owned vitamin and supplement company.” (their page)
Bromelain supports healthy breathing and nasal health.
Unresolvedhealth and safety evidence
Studied in: people with sinusitis.
Measured as an outcome.
- Bromelain: Usefulness and Safety (Regulatory) · Funding not checked
- Efficacy and safety of bromelain: A systematic review and meta-analysis (Peer-reviewed) · Funding not checked
Who’s saying this
- Life Extension — a brand: sells its own vitamins and supplements
How we know who this is
- “Life Extension is a privately owned vitamin and supplement company.” (their page)
Bromelain benefits the joints.
Unresolvedhealth and safety evidence
Studied in: adults with osteoarthritis.
Measured as an outcome.
- The effects of bromelain on osteoarthritis symptoms: A systematic review (Peer-reviewed) · Funding not checked
- Bromelain: Usefulness and Safety (Regulatory) · Funding not checked
Who’s saying this
- Life Extension — a brand: sells its own vitamins and supplements
How we know who this is
- “Life Extension is a privately owned vitamin and supplement company.” (their page)
Bromelain improves digestive health, comfort and regularity.
Not gradedhealth and safety evidence
Sources cited — no verdict reached.
What was measured is not yet noted.
- Effects of bromelain supplementation on disease activity and quality of life in patients with ulcerative colitis: a randomized, triple-blind, placebo-controlled study (Peer-reviewed) · Funding not checked · No conflicts declared
- Bromelain: Usefulness and Safety (Regulatory) · Funding not checked
Who’s saying this
- Life Extension — a brand: sells its own vitamins and supplements
How we know who this is
- “Life Extension is a privately owned vitamin and supplement company.” (their page)