“Button mushroom?”Here!Agaricus bisporus
Hasn’t appeared in a scanned product yet.
As a supplement
Talk to your doctor or pharmacist.
Roll Call does not check drug interactions or assess personal safety.
The common white or brown culinary mushroom, dried or powdered for use as a food ingredient or supplement.
Why it’s used
Included for its nutrient content — including some fiber, B vitamins, and, when exposed to UV light during growing, vitamin D — or simply as a whole-food ingredient.
What the evidence says
Button mushroom is a well-established food, but as a standalone supplement ingredient it has little dedicated clinical research behind specific health claims. Any vitamin D content depends heavily on UV exposure during cultivation and is not standardized across products.
Where we looked
There was no paper to cite here, so this is the search instead — run it yourself and see what we saw.
- PubMed: 263 records · searched September 2026
"Agaricus bisporus"[Title/Abstract] AND (review[pt] OR "safety assessment"[Title/Abstract] OR "risk assessment"[Title/Abstract] OR toxicology[Title/Abstract] OR toxicity[Title/Abstract] OR characterization[Title/Abstract] OR characterisation[Title/Abstract]) - PubMed: 3 records · searched September 2026
"Agaricus bisporus"[Title/Abstract] AND ("dietary supplements"[MeSH] OR supplementation[Title/Abstract] OR supplement[Title/Abstract] OR supplements[Title/Abstract] OR "oral administration"[Title/Abstract]) AND (randomized controlled trial[pt] OR clinical trial[pt] OR meta-analysis[pt] OR systematic review[pt]) AND humans[MeSH] - PubMed: 1775 records · searched September 2026
"Agaricus bisporus"[Title/Abstract]
This says what this database holds under these terms. It is not a finding that no research exists.
Context
No consistent dosing protocol appears in the literature, as most research on this mushroom concerns its nutrient composition rather than a tested therapeutic dose.
Rumors
Button mushrooms contain agaritine, a toxin that may cause cancer.
Supports — suggestivehealth and safety evidence
Measured as a biomarker.
- Agaritine (IARC Summary & Evaluation, Volume 31, 1983) (Regulatory) · Funding not checked
- Warning on False or True Morels and Button Mushrooms with Potential Toxicity Linked to Hydrazinic Toxins: An Update (Peer-reviewed) · Funding not clearly stated · No conflicts declared
Who’s saying this
- NutritionFacts.org — an advocacy group: promotes whole food, plant-based diet; nonprofit
How we know who this is
- “NutritionFacts.org is a science-based nonprofit charity committed to bringing the medical literature to you, breaking down the latest in evidence-based nutrition research, and presenting the results in ways that are easy to understand.” (their page)
- “We also disseminate fact-based information through social media on the benefits of a whole food, plant-based diet for wellness, disease prevention, healthy weight management, and longevity.” (their page)
White button mushroom extract protects cells from oxidative stress.
Does not support — suggestivehealth and safety evidence
Measured as a biomarker.
- The bioavailability of ergothioneine from mushrooms (Agaricus bisporus) and the acute effects on antioxidant capacity and biomarkers of inflammation (Peer-reviewed) · Funding not checked
Who’s saying this
- BulkSupplements.com — a brand: sells nutritional supplement ingredients
How we know who this is
- “Located in Henderson, Nevada, BulkSupplements.com supplies over 500 pure nutritional supplement ingredients to hundreds of thousands of consumers and manufacturers.” (their page)
White button mushroom extract supports immune system function.
Supports — suggestivehealth and safety evidence
Studied in: prostate cancer patients under active surveillance.
Measured as a biomarker.
- Reduction of myeloid‐derived suppressor cells in prostate cancer murine models and patients following white button mushroom treatment (Peer-reviewed) · Funded by NIH; Panda Charitable Foundation (government) · No conflicts declared
Who’s saying this
- BulkSupplements.com — a brand: sells nutritional supplement ingredients
How we know who this is
- “Located in Henderson, Nevada, BulkSupplements.com supplies over 500 pure nutritional supplement ingredients to hundreds of thousands of consumers and manufacturers.” (their page)
White button mushroom supplements slow prostate cancer growth.
Supports — suggestivehealth and safety evidence
Studied in: prostate cancer patients (early-stage/low-risk or biochemically recurrent) consuming WBM tablets in Phase I/II trials.
Measured as a biomarker.
- Reduction of myeloid‐derived suppressor cells in prostate cancer murine models and patients following white button mushroom treatment (Peer-reviewed) · Funded by NIH; Panda Charitable Foundation (government) · No conflicts declared
- Mushrooms | Complementary and Alternative therapy | Cancer Research UK (NGO or audit) · Funding not checked
Who’s saying this
- Pharmacy Times — a publisher: pharmacy news and clinical information for pharmacists
How we know who this is
- “Pharmacy Times® is the industry-leading multimedia resource for community, health system, and specialty pharmacy news.” (their page)