“Cannabidiol?”Here!CBD
Hasn’t appeared in a scanned product yet.
As a supplement
Talk to your doctor or pharmacist.
Roll Call does not check drug interactions or assess personal safety.
A non-intoxicating compound extracted from cannabis (hemp) plants, sold as an oil, capsule, or other supplement form.
Why it’s used
Taken by some for general wellbeing, relaxation, or discomfort, though sold supplements are not the same formulation as the prescription drug version.
What the evidence says
The one well-established use of cannabidiol is as a prescription drug (Epidiolex) for specific rare seizure disorders, approved based on controlled clinical trials — but that is a regulated pharmaceutical, not a dietary supplement. For the broad range of uses supplements are marketed for, such as general anxiety, sleep, or pain, the human evidence is limited and inconsistent, and supplement products vary widely in actual CBD content.
Where we looked
There was no paper to cite here, so this is the search instead — run it yourself and see what we saw.
- PubMed: 2438 records · searched September 2026
"Cannabidiol"[Title/Abstract] AND (review[pt] OR "safety assessment"[Title/Abstract] OR "risk assessment"[Title/Abstract] OR toxicology[Title/Abstract] OR toxicity[Title/Abstract] OR characterization[Title/Abstract] OR characterisation[Title/Abstract]) - PubMed: 45 records · searched September 2026
"Cannabidiol"[Title/Abstract] AND ("dietary supplements"[MeSH] OR supplementation[Title/Abstract] OR supplement[Title/Abstract] OR supplements[Title/Abstract] OR "oral administration"[Title/Abstract]) AND (randomized controlled trial[pt] OR clinical trial[pt] OR meta-analysis[pt] OR systematic review[pt]) AND humans[MeSH] - PubMed: 8540 records · searched September 2026
"Cannabidiol"[Title/Abstract]
This says what this database holds under these terms. It is not a finding that no research exists.
Context
Clinical trials supporting the seizure-disorder drug used doses far higher than typical over-the-counter supplement servings, and were conducted under medical supervision with a specific pharmaceutical formulation.
Rumors
CBD oil treats epilepsy and disease.
We haven’t found evidence strong enough to support this or rule it out.
What was measured is not yet noted.
Who’s saying this
- Goodreads — a platform — posts are by its users: book reviews and recommendations site; Goodreads LLC is a subsidiary of Amazon.com, Inc.
How we know who this is
- “Goodreads is the world’s largest site for readers and book recommendations.” (their page)
- “Goodreads LLC is a subsidiary of Amazon.com, Inc. (“Amazon”).” (their page)
- Goodreads — a platform — posts are by its users: book reviews and recommendations site; Goodreads LLC is a subsidiary of Amazon.com, Inc.
CBD supplements can damage the liver.
We haven’t found evidence strong enough to support this or rule it out.
What was measured is not yet noted.
Who’s saying this
- foodfacts.org — we couldn’t open the site to see who runs it
CBD oil reduces anxiety.
Unresolvedhealth and safety evidence
Measured as an outcome.
- The Impact of Cannabidiol Treatment on Anxiety Disorders: A Systematic Review of Randomized Controlled Clinical Trials (Peer-reviewed) · Funded by Goiás Research Foundation (FAPEG); National Council for Scientific and Technological Development (CNPq) (government) · No conflicts declared
- Cannabidiol for Scan-Related Anxiety in Women With Advanced Breast Cancer: A Randomized Clinical Trial (Peer-reviewed) · Funded by Hans and Mavis Lopater Foundation; Gloria Spivak Faculty Advancement Fund (foundation) · Authors declare a conflict of interest
- Evidence for Use of Cannabinoids in Mood Disorders, Anxiety Disorders, and PTSD: A Systematic Review (Peer-reviewed) · Funding not checked · No conflicts declared
Who’s saying this
- ChoosingTherapy.com — a publisher: mental health publisher that reviews mental health companies and runs the Psychology.com therapist directory
How we know who this is
- “ChoosingTherapy.com is an online publisher with over 3 million monthly readers.” (their page)
- “We also run a directory of local therapists on Psychology.com, free for anyone looking for a mental health provider.” (their page)
CBD improves sleep.
Not gradedhealth and safety evidence
Sources cited — no verdict reached.
What was measured is not yet noted.
- Cannabinoids versus placebo for pain: A systematic review with meta-analysis and Trial Sequential Analysis (Peer-reviewed) · Funded by A.V. Lykfeldt and Wife’s Grant (A.V. Lykfeldt og Hustrus Legat) (foundation) · No conflicts declared
Who’s saying this
- Healthline — a publisher: health information publisher; part of RVO Health, backed by Red Ventures and UnitedHealth Group's Optum
How we know who this is
- “Healthline is a digital publisher and does not offer personal health or medical advice.” (their page)
- “Healthline is part of RVO Health, a company backed by Red Ventures and UnitedHealth Group’s Optum.” (their page)
CBD relieves chronic pain.
Not gradedhealth and safety evidence
Sources cited — no verdict reached.
What was measured is not yet noted.
- Cannabinoids versus placebo for pain: A systematic review with meta-analysis and Trial Sequential Analysis (Peer-reviewed) · Funded by A.V. Lykfeldt and Wife’s Grant (A.V. Lykfeldt og Hustrus Legat) (foundation) · No conflicts declared
Who’s saying this
- Healthline — a publisher: health information publisher; part of RVO Health, backed by Red Ventures and UnitedHealth Group's Optum
How we know who this is
- “Healthline is a digital publisher and does not offer personal health or medical advice.” (their page)
- “Healthline is part of RVO Health, a company backed by Red Ventures and UnitedHealth Group’s Optum.” (their page)