“Catalase?”Here!
Hasn’t appeared in a scanned product yet.
As a supplement
Talk to your doctor or pharmacist.
Roll Call does not check drug interactions or assess personal safety.
An antioxidant enzyme naturally produced by the body and also found in many foods, which breaks down hydrogen peroxide into water and oxygen.
Why it’s used
Taken by some as a general antioxidant supplement.
What the evidence says
Catalase is a protein, and proteins are generally broken down by digestion before absorption, which raises questions about whether an oral catalase supplement can act as intact enzyme in the body. There is little to no clinical trial evidence in humans supporting a specific effect from oral catalase supplementation.
Where we looked
There was no paper to cite here, so this is the search instead — run it yourself and see what we saw.
- PubMed: 14688 records · searched September 2026
"Catalase"[Title/Abstract] AND (review[pt] OR "safety assessment"[Title/Abstract] OR "risk assessment"[Title/Abstract] OR toxicology[Title/Abstract] OR toxicity[Title/Abstract] OR characterization[Title/Abstract] OR characterisation[Title/Abstract]) - PubMed: 222 records · searched September 2026
"Catalase"[Title/Abstract] AND ("dietary supplements"[MeSH] OR supplementation[Title/Abstract] OR supplement[Title/Abstract] OR supplements[Title/Abstract] OR "oral administration"[Title/Abstract]) AND (randomized controlled trial[pt] OR clinical trial[pt] OR meta-analysis[pt] OR systematic review[pt]) AND humans[MeSH] - PubMed: 86731 records · searched September 2026
"Catalase"[Title/Abstract]
This says what this database holds under these terms. It is not a finding that no research exists.
Context
No standardized human dosing studies exist to describe, since clinical research on oral catalase supplementation is essentially absent.
Rumors
Catalase supplements protect your cells' membranes and DNA from damage by hydrogen peroxide.
Not gradedhealth and safety evidence
Sources cited — no verdict reached.
What was measured is not yet noted.
- Solid Lipid Microparticles for Oral Delivery of Catalase: Focus on the Protein Structural Integrity and Gastric Protection (Peer-reviewed) · Funding not checked · No conflicts declared
- Medecine: Extension of murine life span by overexpression of catalase targeted to mitochondria (Peer-reviewed) · Funded by National Institute on Aging (government)
Who’s saying this
- supersmart.com — we couldn’t open the site to see who runs it
Oral catalase breaks down the hydrogen peroxide that builds up in hair follicles and bleaches hair gray.
Not gradedhealth and safety evidence
Sources cited — no verdict reached.
What was measured is not yet noted.
- Senile hair graying: H2O2-mediated oxidative stress affects human hair color by blunting methionine sulfoxide repair (Peer-reviewed) · Funding not checked
- Solid Lipid Microparticles for Oral Delivery of Catalase: Focus on the Protein Structural Integrity and Gastric Protection (Peer-reviewed) · Funding not checked · No conflicts declared
Who’s saying this
- heyhair — a brand: sells anti-gray and hair growth products
How we know who this is
- “This pursuit led to the creation of heyhair, a pioneering brand dedicated to crafting convenient, effective, and affordable hair care solutions powered by science and nature.” (their page)
Catalase supplements fight premature cellular ageing and help prevent age-related diseases.
Does not supporthealth and safety evidence
What was measured is not yet noted.
- Medecine: Extension of murine life span by overexpression of catalase targeted to mitochondria (Peer-reviewed) · Funded by National Institute on Aging (government)
- Solid Lipid Microparticles for Oral Delivery of Catalase: Focus on the Protein Structural Integrity and Gastric Protection (Peer-reviewed) · Funding not checked · No conflicts declared
Who’s saying this
- supersmart.com — we couldn’t open the site to see who runs it
Taking catalase reverses gray hair and restores your natural hair color.
Not gradedhealth and safety evidence
Sources cited — no verdict reached.
What was measured is not yet noted.
- Senile hair graying: H2O2-mediated oxidative stress affects human hair color by blunting methionine sulfoxide repair (Peer-reviewed) · Funding not checked
Who’s saying this
- heyhair — a brand: sells anti-gray and hair growth products
How we know who this is
- “This pursuit led to the creation of heyhair, a pioneering brand dedicated to crafting convenient, effective, and affordable hair care solutions powered by science and nature.” (their page)
Catalase supplements prevent hair from turning grey prematurely.
Not gradedhealth and safety evidence
Sources cited — no verdict reached.
What was measured is not yet noted.
- Premature Graying as a Consequence of Compromised Antioxidant Activity in Hair Bulb Melanocytes and Their Precursors (Peer-reviewed) · Funded by National Natural Science Foundation of China; CMA-L’Oreal China Hair Grant (industry) · Authors declare a conflict of interest
Who’s saying this
- supersmart.com — we couldn’t open the site to see who runs it