“Cellulase?”Here!Cellulase enzyme
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As a supplement
Talk to your doctor or pharmacist.
Roll Call does not check drug interactions or assess personal safety.
Cellulase is an enzyme, typically produced by fungal or microbial fermentation, that breaks down cellulose, the fibrous structural material in plant cell walls, into smaller sugar units.
Why it’s used
Included in some digestive enzyme blends on the theory that it may help break down plant fiber during digestion, since the human digestive tract does not naturally produce enzymes that digest cellulose.
What the evidence says
There is very little published human clinical research on oral cellulase supplements specifically, and no major health authority fact sheet establishes an effect on digestion or nutrient absorption in people. What is known comes mainly from its industrial and laboratory use in breaking down plant fiber outside the body.
Where we looked
There was no paper to cite here, so this is the search instead — run it yourself and see what we saw.
- PubMed: 1873 records · searched September 2026
"Cellulase"[Title/Abstract] AND (review[pt] OR "safety assessment"[Title/Abstract] OR "risk assessment"[Title/Abstract] OR toxicology[Title/Abstract] OR toxicity[Title/Abstract] OR characterization[Title/Abstract] OR characterisation[Title/Abstract]) - PubMed: 1 record · searched September 2026
"Cellulase"[Title/Abstract] AND ("dietary supplements"[MeSH] OR supplementation[Title/Abstract] OR supplement[Title/Abstract] OR supplements[Title/Abstract] OR "oral administration"[Title/Abstract]) AND (randomized controlled trial[pt] OR clinical trial[pt] OR meta-analysis[pt] OR systematic review[pt]) AND humans[MeSH] - PubMed: 11803 records · searched September 2026
"Cellulase"[Title/Abstract]
This says what this database holds under these terms. It is not a finding that no research exists.
Context
Where cellulase has been studied at all in a supplement context, protocols and doses are not standardized across the limited available research, making it difficult to compare studies or draw conclusions about typical use.
Rumors
Cellulase supplements reduce bloating and gas.
Not gradedhealth and safety evidence
Sources cited — no verdict reached.
What was measured is not yet noted.
- A Multi-Digestive Enzyme and Herbal Dietary Supplement Reduces Bloating in a Single Use in Healthy Adults: A Randomized, Placebo-Controlled, Cross Over Study (Peer-reviewed) · Funded by HUM Nutrition, Inc. (industry) · Authors declare a conflict of interest
Who’s saying this
- Wellbeing Nutrition — a brand: sells its own nutritional supplements
How we know who this is
- “Download the Wellbeing Nutrition App.” (their page)
- “We are not just another supplement company.” (their page)
Cellulase supplements can cause mild stomach discomfort or bloating.
Not gradedhealth and safety evidence
Sources cited — no verdict reached.
What was measured is not yet noted.
- A Multi-Digestive Enzyme and Herbal Dietary Supplement Reduces Bloating in a Single Use in Healthy Adults: A Randomized, Placebo-Controlled, Cross Over Study (Peer-reviewed) · Funded by HUM Nutrition, Inc. (industry) · Authors declare a conflict of interest
Who’s saying this
- ALLMAX Nutrition — a brand: sells sports supplements
How we know who this is
- “ALLMAX Nutrition manufactures supplements to pharmaceutical-grade quality standards under cGMP-certified conditions.” (their page)
Cellulase improves nutrient absorption from plant foods.
Not gradedhealth and safety evidence
Sources cited — no verdict reached.
What was measured is not yet noted.
- Acute physiological effects on macromolecule digestion following oral ingestion of the enzyme blend Elevase® in individuals that had undergone an ileostomy, but were otherwise healthy—a randomized, double blinded, placebo-controlled exploratory study (Peer-reviewed) · Funded by Enterprise Ireland (IP20180711) and ADM Cork H&W Limited (previously Deerland Probiotics and Enzymes) (industry) · Authors declare a conflict of interest
Who’s saying this
- SuppCo — a retailer: sells supplements from other brands via its buying club
How we know who this is
- “Today we’re announcing the beta release and seed fundraising round of SuppCo, a new platform to help you make sense of the complex, sprawling landscape of supplements, a $200 billion-a-year industry, and build a plan that’s optimized to your lifestyle and health goals.” (their page)
- “Shop 900+ products from the highest-quality brands and earn 30% in Supp Credits on every dollar spent.” (their page)
Cellulase detoxifies the digestive tract by removing toxins.
We haven’t found evidence strong enough to support this or rule it out.
What was measured is not yet noted.
Who’s saying this
- Wellbeing Nutrition — a brand: sells its own nutritional supplements
How we know who this is
- “Download the Wellbeing Nutrition App.” (their page)
- “We are not just another supplement company.” (their page)
- Wellbeing Nutrition — a brand: sells its own nutritional supplements