Roll Call

“Chrysin?”Here!

Plant

Hasn’t appeared in a scanned product yet.

As a supplement

Talk to your doctor or pharmacist.

Roll Call does not check drug interactions or assess personal safety.

A flavonoid compound found in some plants, honey, and propolis, sold as an isolated supplement ingredient.

Why it’s used

Taken by some in the belief that it may inhibit the enzyme aromatase, with interest particularly among people seeking to influence testosterone-to-estrogen conversion.

What the evidence says

Chrysin has poor oral bioavailability in humans, and available human data do not show that oral supplementation meaningfully raises testosterone or blood chrysin levels high enough to produce the effects seen in laboratory studies. There is no NIH ODS fact sheet on chrysin, and the evidence supporting its marketed use in people is thin.

Where we looked

There was no paper to cite here, so this is the search instead — run it yourself and see what we saw.

  • PubMed: 438 records · searched September 2026"Chrysin"[Title/Abstract] AND (review[pt] OR "safety assessment"[Title/Abstract] OR "risk assessment"[Title/Abstract] OR toxicology[Title/Abstract] OR toxicity[Title/Abstract] OR characterization[Title/Abstract] OR characterisation[Title/Abstract])
  • PubMed: 4 records · searched September 2026"Chrysin"[Title/Abstract] AND ("dietary supplements"[MeSH] OR supplementation[Title/Abstract] OR supplement[Title/Abstract] OR supplements[Title/Abstract] OR "oral administration"[Title/Abstract]) AND (randomized controlled trial[pt] OR clinical trial[pt] OR meta-analysis[pt] OR systematic review[pt]) AND humans[MeSH]
  • PubMed: 2271 records · searched September 2026"Chrysin"[Title/Abstract]

This says what this database holds under these terms. It is not a finding that no research exists.

Context

Most of the mechanistic support for chrysin comes from in vitro or animal studies at exposures not achieved through oral human dosing.

Insufficient dataToo little has been studied to say either way.

Rumors

  1. Chrysin blocks estrogen in the body.

    Does not support — suggestivehealth and safety evidence

    Studied in: healthy men aged 30-59 taking an oral herbal supplement containing chrysin (625 mg/day) combined with androstenedione, DHEA and other herbs for 28 days.

    Measured as a biomarker.

    Who’s saying this

  2. Chrysin increases bleeding risk.

    We haven’t found evidence strong enough to support this or rule it out.

    What was measured is not yet noted.

    Who’s saying this

    • RxList — a publisher: drug information resource; owned by WebMD
      How we know who this is
      • “RxList is an online medical resource dedicated to offering detailed and current pharmaceutical information on brand and generic drugs.” (their page)
      • “RxList.com - Owned and Operated by WebMD and part of the WebMD network.” (their page)

  3. Chrysin supplements help build lean muscle.

    We haven’t found evidence strong enough to support this or rule it out.

    What was measured is not yet noted.

    Who’s saying this

    • MRM Nutrition — a brand: sells its own nutritional supplements
      How we know who this is
      • “At MRM Nutrition, we create premium supplements rooted in the wisdom of nature and backed by the latest in nutritional science.” (their page)

  4. Chrysin treats anxiety.

    We haven’t found evidence strong enough to support this or rule it out.

    What was measured is not yet noted.

    Who’s saying this

  5. Chrysin raises testosterone levels by inhibiting the aromatase enzyme.

    Does not support — suggestivehealth and safety evidence

    Studied in: healthy adult males, 25-30 years old.

    Measured as a biomarker.

    Who’s saying this

    • MRM Nutrition — a brand: sells its own nutritional supplements
      How we know who this is
      • “At MRM Nutrition, we create premium supplements rooted in the wisdom of nature and backed by the latest in nutritional science.” (their page)