“Chymotrypsin?”Here!
Hasn’t appeared in a scanned product yet.
As a supplement
Talk to your doctor or pharmacist.
Roll Call does not check drug interactions or assess personal safety.
A protein-digesting enzyme normally produced by the pancreas, here purified (often from animal pancreatic tissue) for use in supplements and enzyme blends.
Why it’s used
Taken as part of proteolytic enzyme blends intended to support protein digestion or, in some formulations, marketed for post-exercise recovery or minor swelling.
What the evidence says
Chymotrypsin is well characterized as a digestive enzyme in its natural role, but oral supplementation faces the basic problem that stomach acid and other digestive enzymes can break it down before it acts as intended. Clinical evidence for oral chymotrypsin supplements producing a meaningful effect in healthy people is very limited.
Where we looked
There was no paper to cite here, so this is the search instead — run it yourself and see what we saw.
- PubMed: 2288 records · searched September 2026
"Chymotrypsin"[Title/Abstract] AND (review[pt] OR "safety assessment"[Title/Abstract] OR "risk assessment"[Title/Abstract] OR toxicology[Title/Abstract] OR toxicity[Title/Abstract] OR characterization[Title/Abstract] OR characterisation[Title/Abstract]) - PubMed: 14 records · searched September 2026
"Chymotrypsin"[Title/Abstract] AND ("dietary supplements"[MeSH] OR supplementation[Title/Abstract] OR supplement[Title/Abstract] OR supplements[Title/Abstract] OR "oral administration"[Title/Abstract]) AND (randomized controlled trial[pt] OR clinical trial[pt] OR meta-analysis[pt] OR systematic review[pt]) AND humans[MeSH] - PubMed: 17511 records · searched September 2026
"Chymotrypsin"[Title/Abstract]
This says what this database holds under these terms. It is not a finding that no research exists.
Context
Most study of chymotrypsin's action comes from its physiological role in digestion rather than from trials of oral supplement products; dosing in commercial blends varies widely and has not been standardized against outcomes.
Rumors
Chymotrypsin supplements reduce muscle soreness and speed muscle recovery after exercise.
We haven’t found evidence strong enough to support this or rule it out.
What was measured is not yet noted.
Who’s saying this
- Healthline — a publisher: health information publisher; part of RVO Health, backed by Red Ventures and UnitedHealth Group's Optum
How we know who this is
- “Healthline is a digital publisher and does not offer personal health or medical advice.” (their page)
- “Healthline is part of RVO Health, a company backed by Red Ventures and UnitedHealth Group’s Optum.” (their page)
- Healthline — a publisher: health information publisher; part of RVO Health, backed by Red Ventures and UnitedHealth Group's Optum
Chymotrypsin speeds up the repair of tendons, ligaments, and muscles.
Not gradedhealth and safety evidence
Sources cited — no verdict reached.
What was measured is not yet noted.
Who’s saying this
- Dee Cee Laboratories Inc. — a brand: sells vitamins and supplements
How we know who this is
- “© 2026 Dee Cee Laboratories Inc.” (their page)
- “Dee Cee Laboratories Vitamins and Supplements” (their page)
- Dee Cee Laboratories Inc. — a brand: sells vitamins and supplements
Chymotrypsin reduces swelling and inflammation.
Supports — suggestivehealth and safety evidence
Studied in: postoperative surgical patients (orthopedic surgery and third molar extraction).
Measured as an outcome.
- A Randomized, Clinical Trial to Evaluate Efficacy and Tolerability of Trypsin:Chymotrypsin as Compared to Serratiopeptidase and Trypsin:Bromelain:Rutoside in Wound Management (Peer-reviewed) · Funding not checked
- Comparison of Efficacy of Coumarin and Chymotrypsin/Trypsin in Patients Undergoing Surgical Removal of Lower Third Molars: A Prospective Study (Peer-reviewed) · Funding not checked · No conflicts declared
Who’s saying this
- RxList — a publisher: drug information resource; owned by WebMD
How we know who this is
- “RxList is an online medical resource dedicated to offering detailed and current pharmaceutical information on brand and generic drugs.” (their page)
- “RxList.com - Owned and Operated by WebMD and part of the WebMD network.” (their page)
Chymotrypsin can cause allergic reactions when taken by mouth.
Sources cited — check not cleared.
Studied in: patients with pancreatic insufficiency (e.g., cystic fibrosis) taking oral pancreatic enzyme pharmaceutical preparations.
Measured as an outcome.
- Safety evaluation of a food enzyme containing trypsin and chymotrypsin from porcine pancreas (Regulatory) · Funding not checked
Who’s saying this
- RxList — a publisher: drug information resource; owned by WebMD
How we know who this is
- “RxList is an online medical resource dedicated to offering detailed and current pharmaceutical information on brand and generic drugs.” (their page)
- “RxList.com - Owned and Operated by WebMD and part of the WebMD network.” (their page)
Chymotrypsin reduces inflammation more than aspirin.
Supports — suggestivehealth and safety evidence
Studied in: albino rats with carrageenan-induced paw edema and cotton pellet granuloma.
Measured as an outcome.
- Effect of Some Clinically Used Proteolytic Enzymes on Inflammation in Rats (Peer-reviewed) · Funding not checked
Who’s saying this
- Healthline — a publisher: health information publisher; part of RVO Health, backed by Red Ventures and UnitedHealth Group's Optum
How we know who this is
- “Healthline is a digital publisher and does not offer personal health or medical advice.” (their page)
- “Healthline is part of RVO Health, a company backed by Red Ventures and UnitedHealth Group’s Optum.” (their page)