Roll Call

“Creatinol-O-Phosphate?”Here!COP

Synthetic

Hasn’t appeared in a scanned product yet.

As a supplement

Talk to your doctor or pharmacist.

Roll Call does not check drug interactions or assess personal safety.

A synthetic compound structurally related to creatine, developed originally for cardiovascular research and later adopted into some sports and energy supplement formulas.

Why it’s used

Taken by some as an energy or performance supplement, on the premise that it supports cellular energy metabolism similarly to creatine.

What the evidence says

Human evidence for oral supplementation with creatinol-O-phosphate is sparse. It is chemically distinct from creatine, and creatine's own body of evidence does not transfer to this compound. No major systematic review or regulatory body has evaluated it.

Where we looked

There was no paper to cite here, so this is the search instead — run it yourself and see what we saw.

  • PubMed: 2 records · searched September 2026"Creatinol-O-Phosphate"[Title/Abstract] AND (review[pt] OR "safety assessment"[Title/Abstract] OR "risk assessment"[Title/Abstract] OR toxicology[Title/Abstract] OR toxicity[Title/Abstract] OR characterization[Title/Abstract] OR characterisation[Title/Abstract])
  • PubMed: 0 records · searched September 2026"Creatinol-O-Phosphate"[Title/Abstract] AND ("dietary supplements"[MeSH] OR supplementation[Title/Abstract] OR supplement[Title/Abstract] OR supplements[Title/Abstract] OR "oral administration"[Title/Abstract]) AND (randomized controlled trial[pt] OR clinical trial[pt] OR meta-analysis[pt] OR systematic review[pt]) AND humans[MeSH]
  • PubMed: 45 records · searched September 2026"Creatinol-O-Phosphate"[Title/Abstract]

This says what this database holds under these terms. It is not a finding that no research exists.

Context

Available research is limited in scope and mostly predates current standards for supplement clinical trials.

Insufficient dataToo little has been studied to say either way.

Rumors

  1. Creatinol-O-phosphate protects the heart and helps against arrhythmia.

    We haven’t found evidence strong enough to support this or rule it out.

    What was measured is not yet noted.

    Who’s saying this

    • Nutracap — a brand: contract and private-label dietary supplement manufacturer
      How we know who this is
      • “Based in Atlanta, GA, Nutracap is a manufacturer of Nutraceuticals/Dietary Supplements and we are experiencing explosive growth.” (their page)
      • “Private Label manufacturing is the fastest growing sector of our business and our biggest strength due to the relationships we have built with our customers.” (their page)
  2. Creatinol-O-phosphate has no side effects.

    We haven’t found evidence strong enough to support this or rule it out.

    What was measured is not yet noted.

    Who’s saying this

  3. Creatinol-O-phosphate is a great supplement for endurance sports.

    We haven’t found evidence strong enough to support this or rule it out.

    What was measured is not yet noted.

    Who’s saying this

  4. Creatinol-O-phosphate delays muscle fatigue and improves endurance by buffering lactic acid buildup.

    We haven’t found evidence strong enough to support this or rule it out.

    What was measured is not yet noted.

    Who’s saying this

    • Sunland Nutrition Inc. — a retailer: distributes nutritional ingredients
      How we know who this is
      • “Sunland Nutrition Inc. is a premier distributor for full line of nutritional ingredients and sourcing hundreds ingredients for its in-stock program, with facilities in Los Angeles and New Jersey.” (their page)
  5. Creatinol-O-phosphate helps prevent muscle loss, including muscle loss from GLP-1 drugs.

    We haven’t found evidence strong enough to support this or rule it out.

    What was measured is not yet noted.

    Who’s saying this