Creatinol-O-Phosphate — answers to COP
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A synthetic compound structurally related to creatine, developed originally for cardiovascular research and later adopted into some sports and energy supplement formulas.
Why it’s used
Taken by some as an energy or performance supplement, on the premise that it supports cellular energy metabolism similarly to creatine.
What the evidence says
Human evidence for oral supplementation with creatinol-O-phosphate is sparse. It is chemically distinct from creatine, and creatine's own body of evidence does not transfer to this compound. No major systematic review or regulatory body has evaluated it.
Where we looked
There was no paper to cite here, so this is the search instead — run it yourself and see what we saw.
- PubMed: 0 records · searched August 2026
"Creatinol-O-Phosphate"[Title/Abstract] AND ("dietary supplements"[MeSH] OR supplementation[Title/Abstract] OR supplement[Title/Abstract] OR supplements[Title/Abstract] OR "oral administration"[Title/Abstract]) AND (randomized controlled trial[pt] OR clinical trial[pt] OR meta-analysis[pt] OR systematic review[pt]) AND humans[MeSH] - PubMed: 45 records · searched August 2026
"Creatinol-O-Phosphate"[Title/Abstract]
This says what this database holds under these terms. It is not a finding that no research exists.
Context
Available research is limited in scope and mostly predates current standards for supplement clinical trials.
Educational information, not medical or safety advice. Consult a professional for allergies or medical concerns.