Roll Call

“Dimethylglycine?”Here!DMG

Synthetic

Hasn’t appeared in a scanned product yet.

As a supplement

Talk to your doctor or pharmacist.

Roll Call does not check drug interactions or assess personal safety.

A small amino-acid derivative found naturally in low amounts in some foods, and produced synthetically for supplement use.

Why it’s used

Marketed for energy, athletic performance, and general immune support.

What the evidence says

Human clinical evidence for dimethylglycine is sparse and mostly limited to small or older studies that did not consistently show meaningful effects. It has not been evaluated in the kind of large, well-controlled trials that would support a firm conclusion either way.

Where we looked

There was no paper to cite here, so this is the search instead — run it yourself and see what we saw.

  • PubMed: 103 records · searched September 2026"Dimethylglycine"[Title/Abstract] AND (review[pt] OR "safety assessment"[Title/Abstract] OR "risk assessment"[Title/Abstract] OR toxicology[Title/Abstract] OR toxicity[Title/Abstract] OR characterization[Title/Abstract] OR characterisation[Title/Abstract])
  • PubMed: 32 records · searched September 2026"Dimethylglycine"[Title/Abstract] AND ("dietary supplements"[MeSH] OR supplementation[Title/Abstract] OR supplement[Title/Abstract] OR supplements[Title/Abstract] OR "oral administration"[Title/Abstract]) AND (randomized controlled trial[pt] OR clinical trial[pt] OR meta-analysis[pt] OR systematic review[pt]) AND humans[MeSH]
  • PubMed: 826 records · searched September 2026"Dimethylglycine"[Title/Abstract]

This says what this database holds under these terms. It is not a finding that no research exists.

Context

No standardized dosing protocol has emerged from the limited research available.

Insufficient dataToo little has been studied to say either way.

Rumors

  1. DMG is an extremely safe, hypoallergenic supplement with no side effects.

    Supports — suggestivehealth and safety evidence

    Studied in: patients with progressive multiple sclerosis.

    Measured as an outcome.

    Who’s saying this

  2. DMG reduces lactic acid build-up, improving endurance and recovery.

    Does not support — suggestivehealth and safety evidence

    Studied in: male track athletes.

    Measured as a biomarker.

    Who’s saying this

    • PureBulk — a brand: sells pure dietary supplement powders, oils and capsules
      How we know who this is
      • “PureBulk was founded in 2008 by Timothy McNulty with a simple idea, that people can save money by buying the dietary supplements they want, without the fillers and additives.” (their page)
      • “PureBulk offers a variety of over 250 pure dietary powders, oils and capsules as well as the tools necessary for you to accurately measure your supplements and make your own custom supplement blends and formulations using your own ingredients.” (their page)

  3. DMG supplements boost/support the immune system.

    Supports — suggestivehealth and safety evidence

    Measured as a biomarker.

    Who’s saying this

  4. DMG improves speech and behavior in children with autism.

    Sources cited — check not cleared.

    Studied in: children aged 3-11 with autism or pervasive developmental disorder.

    Measured as an outcome.

    Who’s saying this

    • Dr. Roger V. Kendall — an individual: author of a book promoting DMG
      How we know who this is
      • “Dr. Roger V. Kendall, Ph.D., is considered to be the leading expert in the biochemistry and health benefits of DMG.” (their page)
      • “Dr. Kendall has compiled his research and clinical experience with DMG in his well received book entitled "Building Wellness with DMG."” (their page)

  5. DMG enhances athletic performance.

    Does not support — establishedhealth and safety evidence

    Measured as an outcome.

    Who’s saying this