Evodiamine
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Evodiamine is an alkaloid found in the fruit of Evodia rutaecarpa (also called Tetradium ruticarpum), a plant used in traditional Chinese medicine. It has been isolated for study as a single compound rather than the whole herb.
Why it’s used
Taken by some for weight management, based on its marketing as a thermogenic or metabolism-supporting compound.
What the evidence says
Evidence in humans is essentially absent. Most available research is in cell or animal models examining effects on thermogenesis and fat metabolism, which do not reliably translate to effects in people. There is no NIH ODS fact sheet or established human clinical evidence.
Where we looked
There was no paper to cite here, so this is the search instead — run it yourself and see what we saw.
- PubMed: 1 record · searched August 2026
"Evodiamine"[Title/Abstract] AND ("dietary supplements"[MeSH] OR supplementation[Title/Abstract] OR supplement[Title/Abstract] OR supplements[Title/Abstract] OR "oral administration"[Title/Abstract]) AND (randomized controlled trial[pt] OR clinical trial[pt] OR meta-analysis[pt] OR systematic review[pt]) AND humans[MeSH] - PubMed: 706 records · searched August 2026
"Evodiamine"[Title/Abstract]
This says what this database holds under these terms. It is not a finding that no research exists.
Context
Animal studies have used a range of doses by body weight that cannot be directly translated to a human amount, and no established human dosing protocol exists in the published literature.
Educational information, not medical or safety advice. Consult a professional for allergies or medical concerns.