Genistein — answers to soy isoflavone
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A naturally occurring isoflavone found in soybeans and other legumes, structurally similar enough to estrogen that it binds weakly to estrogen receptors.
Why it’s used
Taken by some for menopausal symptoms such as hot flashes, and studied for possible effects on bone and cardiovascular markers.
What the evidence is for
menopausal hot flash symptom relief.
What the evidence says
A Cochrane review of phytoestrogens, including soy isoflavones such as genistein, found the evidence for relief of menopausal vasomotor symptoms to be limited and inconsistent across trials.
Context
Trials generally ran 12 weeks or longer at varying isoflavone doses, and individual response has been linked to differences in gut bacteria's ability to metabolize isoflavones into active compounds.
Educational information, not medical or safety advice. Consult a professional for allergies or medical concerns.