“Glucoraphanin?”Here!
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As a supplement
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Glucoraphanin is a compound found in broccoli and other cruciferous vegetables, particularly concentrated in broccoli sprouts. In the body or during food processing, an enzyme (myrosinase) converts it into sulforaphane, the compound most associated with broccoli's studied effects.
Why it’s used
Taken to support antioxidant and detoxification pathways, largely through its conversion to sulforaphane.
What the evidence says
There is no NIH ODS fact sheet for glucoraphanin specifically. Human research more often studies sulforaphane or broccoli sprout extracts than glucoraphanin itself, and conversion efficiency varies by product and by the individual's gut bacteria, which complicates drawing firm conclusions about glucoraphanin as a standalone ingredient.
Context
Studies of broccoli sprout extracts have used various glucoraphanin-to-sulforaphane ratios and doses, and myrosinase activity in a given product significantly affects how much sulforaphane is actually produced and absorbed.
Rumors
Glucoraphanin neutralizes free radicals and enhances detoxification of cells.
Supports — suggestivehealth and safety evidence
Measured as a biomarker.
- Oral Glucoraphanin and Curcumin Supplements Modulate Key Cytoprotective Enzymes in the Skin of Healthy Human Subjects: A Randomized Trial (Peer-reviewed) · Funded by The Cullman Chemoprotection Center, The Brassica Foundation for Chemoprotection Research, The Lewis B. & Dorothy Cullman Foundation (foundation) · No conflicts declared
- Modulation of the metabolism of airborne pollutants by glucoraphanin-rich and sulforaphane-rich broccoli sprout beverages in Qidong, China (Peer-reviewed) · Funded by USPHS; Prevent Cancer Foundation (government) · No conflicts declared
- Randomized Crossover Trial Evaluating Detoxification of Tobacco Carcinogens by Broccoli Seed and Sprout Extract in Current Smokers (Peer-reviewed) · Funded by U.S. National Cancer Institute (NCI) Division of Cancer Prevention (government) · No conflicts declared
Who’s saying this
- brassica.com — we couldn’t open the site to see who runs it
Glucoraphanin provides antioxidant action that lasts up to 72 hours, far longer than other antioxidants.
We haven’t found evidence strong enough to support this or rule it out.
What was measured is not yet noted.
Who’s saying this
- brassica.com — we couldn’t open the site to see who runs it
Glucoraphanin promotes healthy liver and kidney function.
Supports — suggestivehealth and safety evidence
Studied in: healthy middle-aged Japanese adults (45–65y) with high-normal serum hepatic biomarkers.
Measured as a biomarker.
- Effects of broccoli sprout supplements enriched in glucoraphanin on liver functions in healthy middle-aged adults with high-normal serum hepatic biomarkers: A randomized controlled trial (Peer-reviewed) · Funded by KAGOME Co., Ltd. (industry) · Authors declare a conflict of interest
Who’s saying this
- brassica.com — we couldn’t open the site to see who runs it
Glucoraphanin eliminates harmful toxins from the body (detoxifies).
Supports — suggestivehealth and safety evidence
Studied in: adults in a region with high airborne pollutant exposure (Qidong, China) and current tobacco smokers.
Measured as a biomarker.
- Rapid and sustainable detoxication of airborne pollutants by broccoli sprout beverage: Results of a randomized clinical trial in China (Peer-reviewed) · Funding not checked
- Randomized Crossover Trial Evaluating Detoxification of Tobacco Carcinogens by Broccoli Seed and Sprout Extract in Current Smokers (Peer-reviewed) · Funded by U.S. National Cancer Institute (NCI) Division of Cancer Prevention (government) · No conflicts declared
- Modulation of the metabolism of airborne pollutants by glucoraphanin-rich and sulforaphane-rich broccoli sprout beverages in Qidong, China (Peer-reviewed) · Funded by USPHS; Prevent Cancer Foundation (government) · No conflicts declared
Who’s saying this
- brassica.com — we couldn’t open the site to see who runs it
Glucoraphanin supports the immune system.
Supports — suggestivehealth and safety evidence
Studied in: healthy non-smoking adults receiving live attenuated influenza vaccine.
Measured as a biomarker.
- Effect of Broccoli Sprouts and Live Attenuated Influenza Virus on Peripheral Blood Natural Killer Cells: A Randomized, Double-Blind Study (Peer-reviewed) · Funding not checked
Who’s saying this
- brassica.com — we couldn’t open the site to see who runs it