“Glucuronolactone?”Here!
Hasn’t appeared in a scanned product yet.
As a supplement
Talk to your doctor or pharmacist.
Roll Call does not check drug interactions or assess personal safety.
A small molecule the body produces naturally in modest amounts as part of glucose metabolism, and which is also manufactured for use as a supplement ingredient.
Why it’s used
Included in some energy drinks and supplement blends, typically alongside caffeine and taurine, in products marketed for alertness or energy.
What the evidence says
There is little independent research isolating glucuronolactone's effects from the caffeine and taurine it is usually paired with, so its own contribution to any reported effect is unclear.
Where we looked
There was no paper to cite here, so this is the search instead — run it yourself and see what we saw.
- PubMed: 13 records · searched September 2026
"Glucuronolactone"[Title/Abstract] AND (review[pt] OR "safety assessment"[Title/Abstract] OR "risk assessment"[Title/Abstract] OR toxicology[Title/Abstract] OR toxicity[Title/Abstract] OR characterization[Title/Abstract] OR characterisation[Title/Abstract]) - PubMed: 4 records · searched September 2026
"Glucuronolactone"[Title/Abstract] AND ("dietary supplements"[MeSH] OR supplementation[Title/Abstract] OR supplement[Title/Abstract] OR supplements[Title/Abstract] OR "oral administration"[Title/Abstract]) AND (randomized controlled trial[pt] OR clinical trial[pt] OR meta-analysis[pt] OR systematic review[pt]) AND humans[MeSH] - PubMed: 198 records · searched September 2026
"Glucuronolactone"[Title/Abstract]
This says what this database holds under these terms. It is not a finding that no research exists.
Context
Most studies involving glucuronolactone examine multi-ingredient energy drink formulas rather than the compound on its own, making it difficult to attribute any observed effect specifically to it.
Rumors
Glucuronolactone boosts energy and enhances athletic performance.
Does not support — suggestivehealth and safety evidence
Measured as an outcome.
- Do energy drinks contain active components other than caffeine? (Peer-reviewed) · Funding not checked
Who’s saying this
- PureBulk — a brand: sells pure dietary supplement powders, oils and capsules
How we know who this is
- “PureBulk was founded in 2008 by Timothy McNulty with a simple idea, that people can save money by buying the dietary supplements they want, without the fillers and additives.” (their page)
- “PureBulk offers a variety of over 250 pure dietary powders, oils and capsules as well as the tools necessary for you to accurately measure your supplements and make your own custom supplement blends and formulations using your own ingredients.” (their page)
Glucuronolactone improves mental performance: reaction time, concentration and memory.
Does not support — suggestivehealth and safety evidence
Measured as an outcome.
- Do energy drinks contain active components other than caffeine? (Peer-reviewed) · Funding not checked
Who’s saying this
- mrsupplement.com.au — we couldn’t open the site to see who runs it
Glucuronolactone is a dangerous stimulant that is banned in America.
Sources cited — check not cleared.
What was measured is not yet noted.
- Red Bull Is Dangerous? (Journalism) · Funding not checked
Who’s saying this
- Snopes.com — a publisher: fact-checking publication; owned by Snopes, Inc, subsidiary of Snopes Media Group, Inc
How we know who this is
- “Snopes.com is an independent publication, owned and operated under "Snopes, Inc," which is a wholly-owned subsidiary of "Snopes Media Group, Inc" (SMG).” (their page)
Glucuronolactone taken with resveratrol supports heart health.
We haven’t found evidence strong enough to support this or rule it out.
What was measured is not yet noted.
Who’s saying this
- PureBulk — a brand: sells pure dietary supplement powders, oils and capsules
How we know who this is
- “PureBulk was founded in 2008 by Timothy McNulty with a simple idea, that people can save money by buying the dietary supplements they want, without the fillers and additives.” (their page)
- “PureBulk offers a variety of over 250 pure dietary powders, oils and capsules as well as the tools necessary for you to accurately measure your supplements and make your own custom supplement blends and formulations using your own ingredients.” (their page)
- PureBulk — a brand: sells pure dietary supplement powders, oils and capsules
Glucuronolactone supports liver health and detoxification by binding to toxins.
Supports — suggestivehealth and safety evidence
Studied in: patients with pulmonary tuberculosis receiving antituberculosis drugs (at risk of drug-induced liver injury).
Measured as a biomarker.
- Efficacy of Jian’ganle (健肝乐) versus Hugan Pian (护肝片), glucuronolactone and reduced glutathione in prevention of antituberculosis drug-induced liver injury (Peer-reviewed) · Funded by Health and Family Planning Commission of Hubei Province (government)
- B Vitamins, Glucoronolactone and the Immune System: Bioavailability, Doses and Efficiency (Peer-reviewed) · Funded by Romanian Ministry of Research and Innovation (government) · No conflicts declared
Who’s saying this
- PureBulk — a brand: sells pure dietary supplement powders, oils and capsules
How we know who this is
- “PureBulk was founded in 2008 by Timothy McNulty with a simple idea, that people can save money by buying the dietary supplements they want, without the fillers and additives.” (their page)
- “PureBulk offers a variety of over 250 pure dietary powders, oils and capsules as well as the tools necessary for you to accurately measure your supplements and make your own custom supplement blends and formulations using your own ingredients.” (their page)