“Hordenine?”Here!
Hasn’t appeared in a scanned product yet.
As a supplement
Talk to your doctor or pharmacist.
Roll Call does not check drug interactions or assess personal safety.
A compound found naturally in barley and some other plants, chemically related to tyramine. It appears in some "fat burner" and pre-workout supplement formulas.
Why it’s used
Taken for purported stimulant or metabolism-supporting effects.
What the evidence says
Hordenine has been studied mainly in animal and laboratory (in vitro) research. There is essentially no published human clinical trial data on oral hordenine supplementation, so claims about fat loss or stimulant effects in people are not backed by direct human evidence.
Where we looked
There was no paper to cite here, so this is the search instead — run it yourself and see what we saw.
- PubMed: 17 records · searched September 2026
"Hordenine"[Title/Abstract] AND (review[pt] OR "safety assessment"[Title/Abstract] OR "risk assessment"[Title/Abstract] OR toxicology[Title/Abstract] OR toxicity[Title/Abstract] OR characterization[Title/Abstract] OR characterisation[Title/Abstract]) - PubMed: 0 records · searched September 2026
"Hordenine"[Title/Abstract] AND ("dietary supplements"[MeSH] OR supplementation[Title/Abstract] OR supplement[Title/Abstract] OR supplements[Title/Abstract] OR "oral administration"[Title/Abstract]) AND (randomized controlled trial[pt] OR clinical trial[pt] OR meta-analysis[pt] OR systematic review[pt]) AND humans[MeSH] - PubMed: 142 records · searched September 2026
"Hordenine"[Title/Abstract]
This says what this database holds under these terms. It is not a finding that no research exists.
Context
No human dosing studies exist to describe.
Rumors
Taking hordenine with other stimulants causes anxiety, racing heart, insomnia, headaches, nausea and dizziness.
Not gradedhealth and safety evidence
Sources cited — no verdict reached.
What was measured is not yet noted.
- Hordenine in Dietary Supplements: Why Avoid It? (Regulatory) · Funding not checked
Who’s saying this
- muscleandstrength.com — we couldn’t open the site to see who runs it
Hordenine raises heart rate and blood pressure.
Supports — suggestivehealth and safety evidence
Measured as an outcome.
- Hordenine in Dietary Supplements: Why Avoid It? (Regulatory) · Funding not checked
Who’s saying this
- Operation Supplement Safety (OPSS) — a government body: Department of Defense dietary supplement and substance program for the military
How we know who this is
- “Operation Supplement Safety (OPSS) is the Department of Defense dietary supplement and substance program for the military” (their page)
Hordenine suppresses appetite.
We haven’t found evidence strong enough to support this or rule it out.
What was measured is not yet noted.
Who’s saying this
- mrsupplement.com.au — we couldn’t open the site to see who runs it
Hordenine boosts energy, focus and mental and physical performance.
Does not supporthealth and safety evidence
Studied in: male strength/power athletes.
Measured as an outcome.
- Examination of a pre-exercise, high energy supplement on exercise performance (Peer-reviewed) · Funded by Vital Pharmaceuticals, Inc. dba VPX/Redline (industry) · Authors declare a conflict of interest
Who’s saying this
- mrsupplement.com.au — we couldn’t open the site to see who runs it
Hordenine helps you lose weight by stimulating norepinephrine release and burning fat.
We haven’t found evidence strong enough to support this or rule it out.
What was measured is not yet noted.
Who’s saying this
- muscleandstrength.com — we couldn’t open the site to see who runs it