Hordenine
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A compound found naturally in barley and some other plants, chemically related to tyramine. It appears in some "fat burner" and pre-workout supplement formulas.
Why it’s used
Taken for purported stimulant or metabolism-supporting effects.
What the evidence says
Hordenine has been studied mainly in animal and laboratory (in vitro) research. There is essentially no published human clinical trial data on oral hordenine supplementation, so claims about fat loss or stimulant effects in people are not backed by direct human evidence.
Where we looked
There was no paper to cite here, so this is the search instead — run it yourself and see what we saw.
- PubMed: 0 records · searched August 2026
"Hordenine"[Title/Abstract] AND ("dietary supplements"[MeSH] OR supplementation[Title/Abstract] OR supplement[Title/Abstract] OR supplements[Title/Abstract] OR "oral administration"[Title/Abstract]) AND (randomized controlled trial[pt] OR clinical trial[pt] OR meta-analysis[pt] OR systematic review[pt]) AND humans[MeSH] - PubMed: 142 records · searched August 2026
"Hordenine"[Title/Abstract]
This says what this database holds under these terms. It is not a finding that no research exists.
Context
No human dosing studies exist to describe.
Educational information, not medical or safety advice. Consult a professional for allergies or medical concerns.