Ipriflavone
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A synthetic compound chemically related to isoflavones found in soy, but not itself a natural plant constituent.
Why it’s used
Taken by some to support bone density, particularly in postmenopausal women.
What the evidence is for
bone density support in postmenopausal women.
What the evidence says
Early trials suggested a possible benefit for bone mineral density, but a large, well-designed trial found no benefit over placebo and raised a safety signal for a drop in white blood cell count (agranulocytosis) in some users, leading several countries to restrict or withdraw it from sale.
Dose studied
600–600 mg — daily dose used in the large postmenopausal bone density trial.
Context
The negative pivotal trial used a dose of 600 mg per day over several years in postmenopausal women; blood cell monitoring was part of that study design because of the observed white cell effect.
Educational information, not medical or safety advice. Consult a professional for allergies or medical concerns.