“isoflavone (unspecified)?”Here!isoflavones (e.g. soy or red clover isoflavones)
Hasn’t appeared in a scanned product yet.
As a supplement
Talk to your doctor or pharmacist.
Roll Call does not check drug interactions or assess personal safety.
A class of plant compounds structurally similar to estrogen, found most notably in soybeans and red clover. Listed without further specification, a label does not indicate the plant source or exact isoflavone composition.
Why it’s used
Taken by some, particularly around menopause, for support with hot flashes or other symptoms attributed to declining estrogen.
What the evidence says
Systematic reviews of soy and other isoflavone supplements for menopausal hot flashes show mixed and generally modest results, with substantial variation depending on the source, dose, and individual metabolism of isoflavones. The evidence supporting a meaningful effect is inconsistent enough that it cannot be called well established, and this entry does not specify which isoflavone source is used.
Context
Trials on isoflavones for menopausal symptoms have used a wide range of doses and preparations, and results differ notably between soy-derived and red-clover-derived products.
Rumors
Isoflavone supplements prevent bone loss as effectively as hormone replacement therapy.
Does not supporthealth and safety evidence
Studied in: postmenopausal women.
Measured as a biomarker.
- Soy: Usefulness and Safety (Regulatory) · Funding not checked
Who’s saying this
- ZOE — a brand: sells gut health products (supplements, foods, app, gut testing)
How we know who this is
- “ZOE is a gut health science company that turns world-leading research into everyday gut health products.” (their page)
- “Our mission is to improve the health of millions, with our supplements and foods, the ZOE app, our free podcast, and gut health testing.” (their page)
Soy isoflavone supplements are not harmful and are safe to try for hot flashes.
Supports — suggestivehealth and safety evidence
Studied in: perimenopausal and postmenopausal women with hot flashes.
Measured as an outcome.
- Soy: Usefulness and Safety (Regulatory) · Funding not checked
- Phytoestrogens for vasomotor menopausal symptoms (Peer-reviewed) · Funding not checked
Who’s saying this
- My Menoplan — a university or research body: menopause information; funded by a National Institute of Aging grant
How we know who this is
- “Copyright My Menoplan | All Rights Reserved © 2020” (their page)
- “Development of this website was funded by a grant from the National Institute of Aging, #R01AG048209.” (their page)
Isoflavones (e.g. from red clover) protect against heart disease by raising HDL cholesterol, preventing blood clots and making arteries more flexible.
Not gradedhealth and safety evidence
Sources cited — no verdict reached.
What was measured is not yet noted.
- Soy: Usefulness and Safety (Regulatory) · Funding not checked
Who’s saying this
- draxe.com — we couldn’t open the site to see who runs it
Soy isoflavone supplements relieve menopause symptoms such as hot flashes, working as well as hormone replacement therapy.
Does not supporthealth and safety evidence
Studied in: perimenopausal and postmenopausal women with vasomotor symptoms.
Measured as an outcome.
- Phytoestrogens for vasomotor menopausal symptoms (Peer-reviewed) · Funding not checked
- Soy: Usefulness and Safety (Regulatory) · Funding not checked
Who’s saying this
- Equelle — a brand: sells S-equol menopause supplement
How we know who this is
- “Equelle is a revolutionary supplement, clinically studied to provide menopause support in 90 days, or your money back.” (their page)
- “Equelle is a game-changing supplement powered by S-equol, a plant-based metabolite that mimics the effects of estrogen to relieve the most bothersome menopausal symptoms.” (their page)
Phytoestrogens such as isoflavones are endocrine disruptors that interfere with the body's hormonal system.
We haven’t found evidence strong enough to support this or rule it out.
A claim about phytoestrogens as a group, not this substance alone.
What was measured is not yet noted.
Who’s saying this
- Healthline — a publisher: health information publisher; part of RVO Health, backed by Red Ventures and UnitedHealth Group's Optum
How we know who this is
- “Healthline is a digital publisher and does not offer personal health or medical advice.” (their page)
- “Healthline is part of RVO Health, a company backed by Red Ventures and UnitedHealth Group’s Optum.” (their page)
- Healthline — a publisher: health information publisher; part of RVO Health, backed by Red Ventures and UnitedHealth Group's Optum