“Isoleucine?”Here!
Hasn’t appeared in a scanned product yet.
As a supplement
Talk to your doctor or pharmacist.
Roll Call does not check drug interactions or assess personal safety.
An essential branched-chain amino acid (BCAA), obtained from dietary protein or supplied as an isolated ingredient, often alongside leucine and valine in BCAA products.
Why it’s used
Taken, typically as part of a BCAA blend, to support muscle recovery and reduce exercise-related muscle breakdown.
What the evidence says
Most human trials examine BCAA blends as a whole rather than isolated isoleucine, so its individual contribution to muscle protein synthesis or recovery is not well separated from that of leucine, which appears to be the primary driver of the effects seen in blend studies.
Context
Blend studies commonly use isoleucine as one component of a mixed BCAA dose totaling a few grams, without isolating an isoleucine-specific dose-response relationship.
Rumors
Isoleucine reduces fatigue and enhances endurance and athletic performance.
Unresolvedhealth and safety evidence
Measured as an outcome.
- Oral Branched-Chain Amino Acids Supplementation in Athletes: A Systematic Review (Peer-reviewed) · Funding not clearly stated · No conflicts declared
- The Effect of Oral Pure Branched-Chain Amino Acid Supplementation on Exercise Performance and Body Composition: A Systematic Review (Peer-reviewed) · Funding not checked
Who’s saying this
- QNT — a brand: sells sports nutrition products
How we know who this is
- “Oui, QNT est une marque belge de nutrition sportive.” (their page)
Isoleucine supplementation reduces muscle soreness and speeds muscle recovery after exercise.
Not gradedhealth and safety evidence
Sources cited — no verdict reached.
What was measured is not yet noted.
- Does Branched-Chain Amino Acids (BCAAs) Supplementation Attenuate Muscle Damage Markers and Soreness after Resistance Exercise in Trained Males? A Meta-Analysis of Randomized Controlled Trials (Peer-reviewed) · Funded by University of Taipei; Ministry of Science and Technology (Taiwan) (government) · No conflicts declared
- The Effect of Oral Pure Branched-Chain Amino Acid Supplementation on Exercise Performance and Body Composition: A Systematic Review (Peer-reviewed) · Funding not checked
Who’s saying this
- mrsupplement.com.au — we couldn’t open the site to see who runs it
Isoleucine supports wound healing and hemoglobin formation.
We haven’t found evidence strong enough to support this or rule it out.
What was measured is not yet noted.
Who’s saying this
- community.bulksupplements.com — the site doesn’t say who runs it
Isoleucine regulates blood sugar and benefits people with or at risk of diabetes.
Does not support — suggestivehealth and safety evidence
Studied in: men with type 2 diabetes.
Measured as an outcome.
- Intragastric administration of leucine and isoleucine does not reduce the glycaemic response to, or slow gastric emptying of, a carbohydrate-containing drink in type 2 diabetes (Peer-reviewed) · Funding not checked
- Comparative Effects of the Branched-Chain Amino Acids, Leucine, Isoleucine and Valine, on Gastric Emptying, Plasma Glucose, C-Peptide and Glucagon in Healthy Men (Peer-reviewed) · Funded by NHMRC (Australia); University of Adelaide scholarships (government) · No conflicts declared
- Genetic Predisposition to an Impaired Metabolism of the Branched-Chain Amino Acids and Risk of Type 2 Diabetes: A Mendelian Randomisation Analysis (Peer-reviewed) · Funded by UK Medical Research Council; EU FP6/FP7; Innovative Medicines Initiative (EFPIA in-kind) (government) · Authors declare a conflict of interest
Who’s saying this
- QNT — a brand: sells sports nutrition products
How we know who this is
- “Oui, QNT est une marque belge de nutrition sportive.” (their page)
Isoleucine supports the immune system.
Supports — suggestivehealth and safety evidence
Studied in: long-distance triathletes and runners after intense endurance exercise.
Measured as a biomarker.
- Branched-chain amino acid supplementation and the immune response of long-distance athletes (Peer-reviewed) · Funding not checked
- l-Isoleucine Administration Alleviates Rotavirus Infection and Immune Response in the Weaned Piglet Model (Peer-reviewed) · Funded by China Agriculture Research System; National Natural Science Foundation of China; Sichuan Province grants (government) · No conflicts declared
Who’s saying this
- mrsupplement.com.au — we couldn’t open the site to see who runs it