L-Alanyl-Glutamine — answers to alanyl-glutamine dipeptide
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A stable dipeptide combining the amino acids alanine and glutamine, manufactured to be more heat- and shelf-stable than free glutamine.
Why it’s used
Taken to support gut barrier function and glutamine availability, particularly around intense exercise or gastrointestinal stress.
What the evidence says
Some clinical research uses alanyl-glutamine in rehydration and clinical nutrition contexts, and small studies suggest possible support for gut integrity under stress such as heat or exercise, but the body of oral-supplement evidence in healthy adults is small and results are inconsistent. It has not been reviewed by NIH ODS.
Where we looked
There was no paper to cite here, so this is the search instead — run it yourself and see what we saw.
- PubMed: 0 records · searched August 2026
"L-Alanyl-Glutamine"[Title/Abstract] AND ("dietary supplements"[MeSH] OR supplementation[Title/Abstract] OR supplement[Title/Abstract] OR supplements[Title/Abstract] OR "oral administration"[Title/Abstract]) AND (randomized controlled trial[pt] OR clinical trial[pt] OR meta-analysis[pt] OR systematic review[pt]) AND humans[MeSH] - PubMed: 18 records · searched August 2026
"L-Alanyl-Glutamine"[Title/Abstract]
This says what this database holds under these terms. It is not a finding that no research exists.
Context
Study protocols vary widely in dose, timing, and population (athletes, clinical patients), making direct comparisons difficult; most trials are small.
Educational information, not medical or safety advice. Consult a professional for allergies or medical concerns.