“L-Alanyl-Glutamine?”Here!alanyl-glutamine dipeptide

Synthetic

Hasn’t appeared in a scanned product yet.

As a supplement

Talk to your doctor or pharmacist.

Roll Call does not check drug interactions or assess personal safety.

A stable dipeptide combining the amino acids alanine and glutamine, manufactured to be more heat- and shelf-stable than free glutamine.

Why it’s used

Taken to support gut barrier function and glutamine availability, particularly around intense exercise or gastrointestinal stress.

What the evidence says

Some clinical research uses alanyl-glutamine in rehydration and clinical nutrition contexts, and small studies suggest possible support for gut integrity under stress such as heat or exercise, but the body of oral-supplement evidence in healthy adults is small and results are inconsistent. It has not been reviewed by NIH ODS.

Where we looked

There was no paper to cite here, so this is the search instead — run it yourself and see what we saw.

PubMed: 1 record · searched September 2026"L-Alanyl-Glutamine"[Title/Abstract] AND (review[pt] OR "safety assessment"[Title/Abstract] OR "risk assessment"[Title/Abstract] OR toxicology[Title/Abstract] OR toxicity[Title/Abstract] OR characterization[Title/Abstract] OR characterisation[Title/Abstract])
PubMed: 0 records · searched September 2026"L-Alanyl-Glutamine"[Title/Abstract] AND ("dietary supplements"[MeSH] OR supplementation[Title/Abstract] OR supplement[Title/Abstract] OR supplements[Title/Abstract] OR "oral administration"[Title/Abstract]) AND (randomized controlled trial[pt] OR clinical trial[pt] OR meta-analysis[pt] OR systematic review[pt]) AND humans[MeSH]
PubMed: 19 records · searched September 2026"L-Alanyl-Glutamine"[Title/Abstract]

This says what this database holds under these terms. It is not a finding that no research exists.

Context

Study protocols vary widely in dose, timing, and population (athletes, clinical patients), making direct comparisons difficult; most trials are small.

Rumors

1
L-alanyl-glutamine supplements cause gastrointestinal side effects such as nausea, bloating and diarrhea.
Does not support — suggestivehealth and safety evidence
Studied in: children at risk of environmental enteropathy in Brazil.
Measured as an outcome.
- Intervention and Mechanisms of Alanyl-glutamine for Inflammation, Nutrition, and Enteropathy: A Randomized Controlled Trial (Peer-reviewed) · Funded by Bill and Melinda Gates Foundation; Fogarty International Center/NIH (foundation) · Authors declare a conflict of interest
Who’s saying this
- Synapse — a brand: pharmaceutical intelligence database; Patsnap product
  How we know who this is
  “Synapse provides users with a 360-degree view of the competitive and technology landscape!” (their page)
  “This report uses Patsnap Analytics, Bio, and Synapse to examine how oligonucleotide IP is evolving across four strategic questions: • Who owns the core patent estate across approved products, clinical candidates, and enabling platforms?” (their page)
2
L-alanyl-glutamine increases endurance and delays exhaustion during exercise.
Supports — suggestivehealth and safety evidence
Studied in: physically active young men undergoing mild dehydration (~2.5% body mass loss) before endurance cycling exercise.
Measured as an outcome.
- Examination of the efficacy of acute L-alanyl-L-glutamine ingestion during hydration stress in endurance exercise (Peer-reviewed) · Funded by Kyowa Hakko Bio Co., Ltd. (industry) · Authors declare a conflict of interest
- L-alanyl-L-glutamine ingestion maintains performance during a competitive basketball game (Peer-reviewed) · Funded by Kyowa Hakko USA (industry) · No conflicts declared
Who’s saying this
- Kyowa Hakko USA — a brand: makes and sells branded supplement ingredients (Cognizin, Setria, etc.); part of Kyowa Hakko Bio within Kirin Holdings
  How we know who this is
  “Kyowa Hakko USA serves as the North and South American headquarters for Kyowa Hakko Bio Co., Ltd., a global pioneer in specialty ingredients within Kirin Holdings’ Health Science group.” (their page)
3
L-alanyl-glutamine (Sustamine) helps the body rehydrate.
Supports — suggestivehealth and safety evidence
Studied in: physically active young men undergoing exercise-induced dehydration.
Measured as an outcome.
- Examination of the efficacy of acute L-alanyl-L-glutamine ingestion during hydration stress in endurance exercise (Peer-reviewed) · Funded by Kyowa Hakko Bio Co., Ltd. (industry) · Authors declare a conflict of interest
- L-alanyl-L-glutamine ingestion maintains performance during a competitive basketball game (Peer-reviewed) · Funded by Kyowa Hakko USA (industry) · No conflicts declared
Who’s saying this
- Cision PRWeb — a platform — posts are by its users: sells online press release distribution packages
  How we know who this is
  “Cision PRWeb is the leader in online news distribution and publicity.” (their page)
  “It offers various online press release packages, enabling users of all kinds to increase the web visibility of their news, reach new audiences, stand out in search, and drive traffic to their websites.” (their page)
4
L-alanyl-glutamine is absorbed more than 200% better than regular L-glutamine.
We haven’t found evidence strong enough to support this or rule it out.
What was measured is not yet noted.
Who’s saying this
- Kyowa Hakko USA — a brand: makes and sells branded supplement ingredients (Cognizin, Setria, etc.); part of Kyowa Hakko Bio within Kirin Holdings
  How we know who this is
  “Kyowa Hakko USA serves as the North and South American headquarters for Kyowa Hakko Bio Co., Ltd., a global pioneer in specialty ingredients within Kirin Holdings’ Health Science group.” (their page)
5
L-alanyl-glutamine improves exercise recovery.
Unresolvedhealth and safety evidence
Studied in: trained athletes (elite triathletes, resistance-trained rats).
Measured as an outcome.
- Role of glutamine, as free or dipeptide form, on muscle recovery from resistance training: a review study (Peer-reviewed) · Funding not checked · No conflicts declared
- Hydrolyzed whey protein enriched with glutamine dipeptide attenuates skeletal muscle damage and improves physical exhaustion test performance in triathletes (Peer-reviewed) · Funded by FAPESP, CNPq, CAPES (government) · No conflicts declared
Who’s saying this
- Kyowa Hakko USA — a brand: makes and sells branded supplement ingredients (Cognizin, Setria, etc.); part of Kyowa Hakko Bio within Kirin Holdings
  How we know who this is
  “Kyowa Hakko USA serves as the North and South American headquarters for Kyowa Hakko Bio Co., Ltd., a global pioneer in specialty ingredients within Kirin Holdings’ Health Science group.” (their page)