Leucic acid — answers to HICA (alpha-hydroxyisocaproic acid)
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A compound derived from the amino acid leucine, sometimes sold as an isolated ingredient in sports supplements.
Why it’s used
Taken by some athletes with an interest in muscle recovery and reducing exercise-related muscle breakdown.
What the evidence says
Human trial data are sparse and small, with mixed results on markers of muscle damage or recovery. There is no NIH ODS fact sheet for this specific compound, and no systematic review establishes a reliable effect.
Where we looked
There was no paper to cite here, so this is the search instead — run it yourself and see what we saw.
- PubMed: 0 records · searched August 2026
"Leucic acid"[Title/Abstract] AND ("dietary supplements"[MeSH] OR supplementation[Title/Abstract] OR supplement[Title/Abstract] OR supplements[Title/Abstract] OR "oral administration"[Title/Abstract]) AND (randomized controlled trial[pt] OR clinical trial[pt] OR meta-analysis[pt] OR systematic review[pt]) AND humans[MeSH] - PubMed: 25 records · searched August 2026
"Leucic acid"[Title/Abstract]
This says what this database holds under these terms. It is not a finding that no research exists.
Context
Small studies have used gram-level daily amounts alongside exercise protocols, but sample sizes are limited and results are not consistent across trials.
Educational information, not medical or safety advice. Consult a professional for allergies or medical concerns.