“Nickel?”Here!

Mineral

Hasn’t appeared in a scanned product yet.

As a supplement

Talk to your doctor or pharmacist.

Roll Call does not check drug interactions or assess personal safety.

A trace metallic element, naturally present in soil, water, and many foods, occasionally included in supplement formulations in trace amounts.

Why it’s used

Not commonly taken deliberately for a specific effect; its presence on a label usually reflects trace mineral content rather than an intended active ingredient.

What the evidence says

Nickel's biological role in humans, if any, is not well established, and it is not classified as an essential nutrient with a defined dietary requirement. Available research is limited and does not support a specific supplement-use claim.

Where we looked

There was no paper to cite here, so this is the search instead — run it yourself and see what we saw.

PubMed: 9068 records · searched September 2026"Nickel"[Title/Abstract] AND (review[pt] OR "safety assessment"[Title/Abstract] OR "risk assessment"[Title/Abstract] OR toxicology[Title/Abstract] OR toxicity[Title/Abstract] OR characterization[Title/Abstract] OR characterisation[Title/Abstract])
PubMed: 13 records · searched September 2026"Nickel"[Title/Abstract] AND ("dietary supplements"[MeSH] OR supplementation[Title/Abstract] OR supplement[Title/Abstract] OR supplements[Title/Abstract] OR "oral administration"[Title/Abstract]) AND (randomized controlled trial[pt] OR clinical trial[pt] OR meta-analysis[pt] OR systematic review[pt]) AND humans[MeSH]
PubMed: 59484 records · searched September 2026"Nickel"[Title/Abstract]

This says what this database holds under these terms. It is not a finding that no research exists.

Context

No studied supplemental dosing protocol for a health benefit has been established in the literature.

Rumors

1
Nickel taken by mouth in supplements causes allergic reactions in people who are sensitive to nickel.
Supports — establishedhealth and safety evidence
Studied in: nickel-sensitised (nickel-allergic) individuals.
Measured as an outcome.
- Systemic contact dermatitis after oral exposure to nickel: a review with a modified meta-analysis (Peer-reviewed) · Funding not checked
- Update of the risk assessment of nickel in food and drinking water (Regulatory) · Funding not checked
- Arsenic, Boron, Nickel, Silicon, and Vanadium (NGO or audit) · Funding not checked
Who’s saying this
- RxList — a publisher: drug information resource; owned by WebMD
  How we know who this is
  “RxList is an online medical resource dedicated to offering detailed and current pharmaceutical information on brand and generic drugs.” (their page)
  “RxList.com - Owned and Operated by WebMD and part of the WebMD network.” (their page)
2
Nickel supports collagen formation and wound healing.
We haven’t found evidence strong enough to support this or rule it out.
What was measured is not yet noted.
Who’s saying this
- StamiLyte — a brand: sells mineral electrolyte drink mix concentrate
  How we know who this is
  “StamiLyte is fully Australian sourced, made and owned.” (their page)
  “StamiLyte is a natural and mineral-rich super electrolyte drink mix concentrate with all the 21 essential minerals and trace elements our bodies need.” (their page)
3
Nickel supplements relieve headaches caused by mental overexertion.
Does not supporthealth and safety evidence
Studied in: electroplating workers acutely exposed to high-dose nickel contamination.
Measured as an outcome.
- Acute nickel toxicity in electroplating workers who accidently ingested a solution of nickel sulfate and nickel chloride (Peer-reviewed) · Funding not checked
Who’s saying this
- nationalnutrition.ca — we couldn’t open the site to see who runs it
4
Nickel supplements help treat anemia from iron deficiency and osteoporosis.
Not gradedhealth and safety evidence
Sources cited — no verdict reached.
What was measured is not yet noted.
- Arsenic, Boron, Nickel, Silicon, and Vanadium (NGO or audit) · Funding not checked
Who’s saying this
- nationalnutrition.ca — we couldn’t open the site to see who runs it
5
High doses of nickel from supplements are poisonous.
Supports — establishedhealth and safety evidence
Measured as an outcome.
- Acute nickel toxicity in electroplating workers who accidently ingested a solution of nickel sulfate and nickel chloride (Peer-reviewed) · Funding not checked
- Arsenic, Boron, Nickel, Silicon, and Vanadium (NGO or audit) · Funding not checked
- Update of the risk assessment of nickel in food and drinking water (Regulatory) · Funding not checked
Who’s saying this
- RxList — a publisher: drug information resource; owned by WebMD
  How we know who this is
  “RxList is an online medical resource dedicated to offering detailed and current pharmaceutical information on brand and generic drugs.” (their page)
  “RxList.com - Owned and Operated by WebMD and part of the WebMD network.” (their page)