Octopamine
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A naturally occurring biogenic amine found in trace amounts in some plants (including bitter orange) and in insects, structurally related to norepinephrine.
Why it’s used
Included in some stimulant or fat-metabolism blends aimed at energy or weight management.
What the evidence says
Human clinical trial data on oral octopamine are sparse; most of what is known comes from animal or in vitro research rather than controlled human studies, so its oral effects in people are not established.
Where we looked
There was no paper to cite here, so this is the search instead — run it yourself and see what we saw.
- PubMed: 3 records · searched August 2026
"Octopamine"[Title/Abstract] AND ("dietary supplements"[MeSH] OR supplementation[Title/Abstract] OR supplement[Title/Abstract] OR supplements[Title/Abstract] OR "oral administration"[Title/Abstract]) AND (randomized controlled trial[pt] OR clinical trial[pt] OR meta-analysis[pt] OR systematic review[pt]) AND humans[MeSH] - PubMed: 2244 records · searched August 2026
"Octopamine"[Title/Abstract]
This says what this database holds under these terms. It is not a finding that no research exists.
Context
No standard human dosing protocol has emerged from the available research.
Educational information, not medical or safety advice. Consult a professional for allergies or medical concerns.