“Octopamine?”Here!
Hasn’t appeared in a scanned product yet.
As a supplement
Talk to your doctor or pharmacist.
Roll Call does not check drug interactions or assess personal safety.
A naturally occurring biogenic amine found in trace amounts in some plants (including bitter orange) and in insects, structurally related to norepinephrine.
Why it’s used
Included in some stimulant or fat-metabolism blends aimed at energy or weight management.
What the evidence says
Human clinical trial data on oral octopamine are sparse; most of what is known comes from animal or in vitro research rather than controlled human studies, so its oral effects in people are not established.
Where we looked
There was no paper to cite here, so this is the search instead — run it yourself and see what we saw.
- PubMed: 336 records · searched September 2026
"Octopamine"[Title/Abstract] AND (review[pt] OR "safety assessment"[Title/Abstract] OR "risk assessment"[Title/Abstract] OR toxicology[Title/Abstract] OR toxicity[Title/Abstract] OR characterization[Title/Abstract] OR characterisation[Title/Abstract]) - PubMed: 3 records · searched September 2026
"Octopamine"[Title/Abstract] AND ("dietary supplements"[MeSH] OR supplementation[Title/Abstract] OR supplement[Title/Abstract] OR supplements[Title/Abstract] OR "oral administration"[Title/Abstract]) AND (randomized controlled trial[pt] OR clinical trial[pt] OR meta-analysis[pt] OR systematic review[pt]) AND humans[MeSH] - PubMed: 2256 records · searched September 2026
"Octopamine"[Title/Abstract]
This says what this database holds under these terms. It is not a finding that no research exists.
Context
No standard human dosing protocol has emerged from the available research.
Rumors
Octopamine burns fat and helps with weight loss.
Not gradedhealth and safety evidence
Sources cited — no verdict reached.
What was measured is not yet noted.
- Adrenergic Metabolic and Hemodynamic Effects of Octopamine in the Liver (Peer-reviewed) · Funded by National Council for Scientific and Technological Development (CNPq) (government) · No conflicts declared
Who’s saying this
- Supplements4muscle.com — a retailer: sells sports and bodybuilding supplements from other brands
How we know who this is
- “Supplements4muscle.com is here to provide you with the products you need to Get Strong, Build Muscle, Burn Fat, Get Fit & Be Healthy.” (their page)
- “Supplements4muscle.com is 100% committed to delivering the highest quality distributor direct supplements.” (their page)
Octopamine is a nootropic that improves focus and motivation.
We haven’t found evidence strong enough to support this or rule it out.
What was measured is not yet noted.
Who’s saying this
- Herb Nutritionals Co., Ltd — a brand: manufactures and supplies bulk supplement ingredients (herbal extracts, amino acids, nootropics, nutraceuticals)
How we know who this is
- “Herb Nutritionals Co., Ltd is a natural product manufacturer and supplier of bulk powders of Herbal Extracts, Amino Acids, Nootropics and Nutraceuticals applied in the dietary supplement industry.” (their page)
- Herb Nutritionals Co., Ltd — a brand: manufactures and supplies bulk supplement ingredients (herbal extracts, amino acids, nootropics, nutraceuticals)
Octopamine gives ephedrine's benefits without dangerous side effects such as large rises in heart rate and blood pressure.
Not gradedhealth and safety evidence
Sources cited — no verdict reached.
What was measured is not yet noted.
- Synephrine in Dietary Supplement Products (Regulatory) · Funding not checked
- Adrenergic Metabolic and Hemodynamic Effects of Octopamine in the Liver (Peer-reviewed) · Funded by National Council for Scientific and Technological Development (CNPq) (government) · No conflicts declared
Who’s saying this
- Herb Nutritionals Co., Ltd — a brand: manufactures and supplies bulk supplement ingredients (herbal extracts, amino acids, nootropics, nutraceuticals)
How we know who this is
- “Herb Nutritionals Co., Ltd is a natural product manufacturer and supplier of bulk powders of Herbal Extracts, Amino Acids, Nootropics and Nutraceuticals applied in the dietary supplement industry.” (their page)
Octopamine is a banned stimulant, and supplements containing it can make athletes fail a drug test.
Sources cited — check not cleared.
Studied in: competitive athletes subject to anti-doping testing.
What was measured is not yet noted.
- Janel Tisinger-Ledkins Accepts Doping Sanction (NGO or audit) · Funding not checked
- Synephrine in Dietary Supplement Products (Regulatory) · Funding not checked
Who’s saying this
- PR-BREAKER — a brand: sells sports supplements (pre-workout, protein, intra-workout)
How we know who this is
- “PR-BREAKER was founded by Derek Charlebois in 2016.” (their page)
- “We’ve since expanded the product line to include 4 additional flavors of MATERIA, MATERIA ZERO (caffeine-free), HITPOINT Protein, and BREAKER-ADE Intra-Workout.” (their page)
Octopamine boosts energy.
Does not supporthealth and safety evidence
Studied in: isolated perfused rat liver (animal/in vitro model, fed and fasted rats).
Measured as a biomarker.
- Adrenergic Metabolic and Hemodynamic Effects of Octopamine in the Liver (Peer-reviewed) · Funded by National Council for Scientific and Technological Development (CNPq) (government) · No conflicts declared
Who’s saying this
- Herb Nutritionals Co., Ltd — a brand: manufactures and supplies bulk supplement ingredients (herbal extracts, amino acids, nootropics, nutraceuticals)
How we know who this is
- “Herb Nutritionals Co., Ltd is a natural product manufacturer and supplier of bulk powders of Herbal Extracts, Amino Acids, Nootropics and Nutraceuticals applied in the dietary supplement industry.” (their page)