“Pepsin?”Here!
Hasn’t appeared in a scanned product yet.
As a supplement
Talk to your doctor or pharmacist.
Roll Call does not check drug interactions or assess personal safety.
A digestive enzyme normally produced in the stomach, where it breaks proteins down into smaller peptides. Supplemental pepsin is usually derived from animal, often porcine, stomach tissue.
Why it’s used
Taken to support protein digestion, frequently paired with betaine hydrochloride or other digestive aids in combination products.
What the evidence says
Pepsin's digestive role inside the body is well understood physiologically, but there is very little clinical research examining whether taking additional pepsin by mouth improves digestion or symptoms in people whose own stomach enzyme production is normal.
Where we looked
There was no paper to cite here, so this is the search instead — run it yourself and see what we saw.
- PubMed: 1856 records · searched September 2026
"Pepsin"[Title/Abstract] AND (review[pt] OR "safety assessment"[Title/Abstract] OR "risk assessment"[Title/Abstract] OR toxicology[Title/Abstract] OR toxicity[Title/Abstract] OR characterization[Title/Abstract] OR characterisation[Title/Abstract]) - PubMed: 9 records · searched September 2026
"Pepsin"[Title/Abstract] AND ("dietary supplements"[MeSH] OR supplementation[Title/Abstract] OR supplement[Title/Abstract] OR supplements[Title/Abstract] OR "oral administration"[Title/Abstract]) AND (randomized controlled trial[pt] OR clinical trial[pt] OR meta-analysis[pt] OR systematic review[pt]) AND humans[MeSH] - PubMed: 13236 records · searched September 2026
"Pepsin"[Title/Abstract]
This says what this database holds under these terms. It is not a finding that no research exists.
Context
No substantial body of dosing trials exists for oral pepsin supplementation outside of its use in replacement therapy for diagnosed enzyme insufficiency.
Rumors
Pepsin supplements relieve gas and bloating.
We haven’t found evidence strong enough to support this or rule it out.
What was measured is not yet noted.
Who’s saying this
- Thorne — a brand: manufactures and sells dietary supplements
How we know who this is
- “Located in Summerville, South Carolina, Thorne manufactures supplements in the USA using globally sourced ingredients.” (their page)
- Thorne — a brand: manufactures and sells dietary supplements
Pepsin supplements improve absorption of vitamin B12 and iron.
We haven’t found evidence strong enough to support this or rule it out.
What was measured is not yet noted.
Who’s saying this
- RTHM — a brand: sells cash-pay medication prescriptions, consultations and clinic care for chronic conditions
How we know who this is
- “RTHM is an intelligent care platform that makes it easy to gather all your health data in one place, connect the dots with AI, and affordably access the diagnostic testing, treatments, and support you need—so healing is finally within reach” (their page)
- “Pay a $49-59 consultation fee + the cost of medication at the pharmacy only if your prescription is approved.” (their page)
- RTHM — a brand: sells cash-pay medication prescriptions, consultations and clinic care for chronic conditions
Pepsin supplements are unsafe for people with peptic ulcers.
We haven’t found evidence strong enough to support this or rule it out.
What was measured is not yet noted.
Who’s saying this
- Thorne — a brand: manufactures and sells dietary supplements
How we know who this is
- “Located in Summerville, South Carolina, Thorne manufactures supplements in the USA using globally sourced ingredients.” (their page)
- Thorne — a brand: manufactures and sells dietary supplements
Supplemental pepsin helps you digest protein and absorb nutrients.
We haven’t found evidence strong enough to support this or rule it out.
What was measured is not yet noted.
Who’s saying this
- Paloma Health — a professional body or practice: online medical practice for hypothyroidism; sells thyroid tests, supplements and treatment
How we know who this is
- “Paloma Health addresses more than just weight and shape changes—we’re here to help with the many symptoms that come with hypothyroidism, perimenopause, and menopause.” (their page)
- Paloma Health — a professional body or practice: online medical practice for hypothyroidism; sells thyroid tests, supplements and treatment
Pepsin supplements improve acid reflux, heartburn and IBS symptoms.
We haven’t found evidence strong enough to support this or rule it out.
What was measured is not yet noted.
Who’s saying this
- draxe.com — we couldn’t open the site to see who runs it