Roll Call

“Phenylalanine?”Here!

Synthetic

Hasn’t appeared in a scanned product yet.

As a supplement

Talk to your doctor or pharmacist.

Roll Call does not check drug interactions or assess personal safety.

An amino acid the body uses to build proteins and, in its L-form, to make tyrosine and downstream neurotransmitters like dopamine and norepinephrine. It occurs naturally in protein-rich foods and is sold in supplement form as L-phenylalanine or DL-phenylalanine.

Why it’s used

Taken by some for mood support or as a building block for neurotransmitter production; DL-phenylalanine has also been explored for pain-related uses.

What the evidence says

Phenylalanine is a well-characterized essential amino acid nutritionally, but clinical evidence for supplemental phenylalanine improving mood or pain is limited and inconsistent, consisting mostly of small or older trials rather than robust modern trials.

Context

Studies of DL-phenylalanine for mood or pain have used varying doses and short durations, and results have not been consistently replicated.

Rumors

  1. DL-phenylalanine improves focus, concentration and mental energy.

    We haven’t found evidence strong enough to support this or rule it out.

    What was measured is not yet noted.

    Who’s saying this

    • Nootropics Depot — a brand: sells supplements
      How we know who this is
      • “Nootropics Depot is located in Tempe Arizona.” (their page)
      • “While we started our journey with nootropics, we now sell many different supplements for all sorts of goals.” (their page)
  2. Phenylalanine supplements (L-phenylalanine and DLPA) boost mood and relieve depression.

    We haven’t found evidence strong enough to support this or rule it out.

    What was measured is not yet noted.

    Who’s saying this

    • iherb.com — we couldn’t open the site to see who runs it
  3. DL-phenylalanine relieves chronic pain by boosting the body's natural endorphins.

    We haven’t found evidence strong enough to support this or rule it out.

    What was measured is not yet noted.

    Who’s saying this

  4. Taking L-phenylalanine orally restores skin pigmentation in vitiligo.

    Not gradedhealth and safety evidence

    Sources cited — no verdict reached.

    What was measured is not yet noted.

    Who’s saying this

  5. L-phenylalanine supplements raise blood pressure.

    Not gradedhealth and safety evidence

    Sources cited — no verdict reached.

    What was measured is not yet noted.

    Who’s saying this