“Phosphatidylethanolamine?”Here!PE
Hasn’t appeared in a scanned product yet.
As a supplement
Talk to your doctor or pharmacist.
Roll Call does not check drug interactions or assess personal safety.
A phospholipid, one of the fat-based molecules that make up cell membranes throughout the body, including in the brain. It is naturally present in foods like soy, eggs, and organ meats, and can be isolated as a supplement ingredient.
Why it’s used
Taken by some for brain or liver support, based on its role as a structural membrane component.
What the evidence says
Direct human trials on phosphatidylethanolamine supplementation are scarce. Most of what is known comes from its basic biology as a membrane lipid rather than from clinical outcome studies, so there isn't a solid evidence base to draw on for any specific effect.
Where we looked
There was no paper to cite here, so this is the search instead — run it yourself and see what we saw.
- PubMed: 2049 records · searched September 2026
"Phosphatidylethanolamine"[Title/Abstract] AND (review[pt] OR "safety assessment"[Title/Abstract] OR "risk assessment"[Title/Abstract] OR toxicology[Title/Abstract] OR toxicity[Title/Abstract] OR characterization[Title/Abstract] OR characterisation[Title/Abstract]) - PubMed: 33 records · searched September 2026
"Phosphatidylethanolamine"[Title/Abstract] AND ("dietary supplements"[MeSH] OR supplementation[Title/Abstract] OR supplement[Title/Abstract] OR supplements[Title/Abstract] OR "oral administration"[Title/Abstract]) AND (randomized controlled trial[pt] OR clinical trial[pt] OR meta-analysis[pt] OR systematic review[pt]) AND humans[MeSH] - PubMed: 21007 records · searched September 2026
"Phosphatidylethanolamine"[Title/Abstract]
This says what this database holds under these terms. It is not a finding that no research exists.
Context
No widely cited human dosing studies exist to describe.
Rumors
Phosphatidylethanolamine supports membrane repair in the brain and nerves.
Not gradedhealth and safety evidence
No sources cited yet.
What was measured is not yet noted.
- Implications of mitochondrial phosphatidylethanolamine in neuronal health and neurodegeneration (Peer-reviewed) · Funded by National Institutes of Health (government) · No conflicts declared
Who’s saying this
- BodyBio — a brand: makes and sells science-backed supplements and vitamins
How we know who this is
- “In 1998, Ed Kane founded BodyBio when he created the first batch of e-lyte in his bathtub.” (their page)
- “Passed down through three generations, our mission remains steadfast: create high-quality, science-backed supplements and vitamins that target the foundation of your health and wellness.” (their page)
Phosphatidylethanolamine protects heart cells from damage.
We haven’t found evidence strong enough to support this or rule it out.
What was measured is not yet noted.
Who’s saying this
- nutriavenue.com — we couldn’t open the site to see who runs it
Phosphatidylethanolamine supplements can cause stomachache and vomiting.
We haven’t found evidence strong enough to support this or rule it out.
What was measured is not yet noted.
Who’s saying this
- nutriavenue.com — we couldn’t open the site to see who runs it
Phosphatidylethanolamine supplements promote liver health and fat metabolism.
Does not support — establishedhealth and safety evidence
Measured as an outcome.
- No effect of an oleoylethanolamide-related phospholipid on satiety and energy intake: a randomised controlled trial of phosphatidylethanolamine (Peer-reviewed) · Funded by Lactopharma New Zealand (industry) · No conflicts declared
- The effect of a dietary supplement (N-oleyl-phosphatidyl-ethanolamine and epigallocatechin gallate) on dietary compliance and body fat loss in adults who are overweight: A double-blind, randomized control trial (Peer-reviewed) · Funded by Chemi Nutra (industry) · No conflicts declared
Who’s saying this
- nutriavenue.com — we couldn’t open the site to see who runs it