Roll Call

“Pyridoxine (Vitamin B6)?”Here!vitamin B6

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As a supplement

Talk to your doctor or pharmacist.

Roll Call does not check drug interactions or assess personal safety.

Pyridoxine is one of the chemical forms of vitamin B6, a water-soluble vitamin the body needs for protein, carbohydrate, and neurotransmitter metabolism.

Why it’s used

Taken to meet daily vitamin B6 requirements and address or prevent deficiency; also used by some for nausea related to pregnancy, under separate clinical guidance.

What the evidence is for

meeting vitamin B6 requirements and correcting deficiency.

What the evidence says

According to the NIH Office of Dietary Supplements, vitamin B6 is well established as essential to metabolic and nervous system function, and oral supplementation reliably corrects deficiency. Evidence for benefits beyond correcting deficiency, such as mood or premenstrual symptoms, is more limited and mixed.

Dose studied

1.3–100 mg — adult RDA up to the tolerable upper intake level, per NIH ODS.

Context

Clinical and nutritional reference intakes are built around the Recommended Dietary Allowance, with a tolerable upper intake level set due to nerve-related effects reported at high, sustained doses in some case studies.

Rumors

  1. Correcting vitamin B6 deficiency, which causes microcytic anemia, cracked lips and a swollen tongue, dermatitis, depression and confusion, and seizures in infants.

    Supports — establishedhealth and safety evidence

    Measured as a biomarker.

How much is a reference amount

  • 1.3 mg a dayfor adults 19–50 · Recommended Dietary Allowance

    Upper limit 100 mg a day, from food and supplements together.

  • 1.5 mg a dayfor adults 51–70, women · Recommended Dietary Allowance

    Upper limit 100 mg a day, from food and supplements together.

  • 1.7 mg a dayfor adults 51–70, men · Recommended Dietary Allowance

    Upper limit 100 mg a day, from food and supplements together.

  • 1.5 mg a dayfor adults 71 and over, women · Recommended Dietary Allowance

    Upper limit 100 mg a day, from food and supplements together.

  • 1.7 mg a dayfor adults 71 and over, men · Recommended Dietary Allowance

    Upper limit 100 mg a day, from food and supplements together.

The worksheet planned one adults_19_plus row for B6. The DRI is age-differentiated: it rises at 51, and it differentiates by sex only from 51 onwards. Five rows, not one.

Every applicable line is shown because we don’t know which one is yours, and a reference intake is a target for a population, not a threshold for harm.