Pyrroloquinoline Quinone — answers to PQQ
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A small quinone compound found in trace amounts in some foods and produced for supplements by fermentation or synthesis.
Why it’s used
Taken by some for claimed support of mitochondrial function, energy, and cognitive performance.
What the evidence is for
cognitive and fatigue-related outcomes in small human trials.
What the evidence says
Human research on PQQ is limited to a small number of small trials, mostly focused on cognitive or fatigue measures, with mixed and preliminary results. It has no NIH ODS fact sheet and no larger body of confirmatory evidence.
Dose studied
10–20 mg — doses used in small human trials of PQQ.
Context
Trials that exist have generally used doses in the range of 10 to 20 mg per day over several weeks, but sample sizes have been small.
Educational information, not medical or safety advice. Consult a professional for allergies or medical concerns.