Roll Call

“Rauwolscine?”Here!alpha-yohimbine

Plant

Hasn’t appeared in a scanned product yet.

As a supplement

Talk to your doctor or pharmacist.

Roll Call does not check drug interactions or assess personal safety.

Rauwolscine is a plant-derived alkaloid closely related in structure to yohimbine, found in the bark of Pausinystalia yohimbe and some other plants. It is sometimes called alpha-yohimbine and is sold as a standalone supplement or in combination fat-loss and pre-workout formulas.

Why it’s used

Taken by some for its stimulant-like effects, often marketed for fat loss, focus, or exercise performance, and frequently included in combination pre-workout or thermogenic products.

What the evidence says

There is no NIH Office of Dietary Supplements fact sheet for rauwolscine specifically. Human clinical research on rauwolscine as an isolated compound is very limited; most of what is known about this class of alkaloids comes from studies of yohimbine, its closer-studied structural relative, which is not the same substance. Claims about fat loss or performance for rauwolscine itself have not been established in controlled human trials.

Where we looked

There was no paper to cite here, so this is the search instead — run it yourself and see what we saw.

  • PubMed: 168 records · searched September 2026"Rauwolscine"[Title/Abstract] AND (review[pt] OR "safety assessment"[Title/Abstract] OR "risk assessment"[Title/Abstract] OR toxicology[Title/Abstract] OR toxicity[Title/Abstract] OR characterization[Title/Abstract] OR characterisation[Title/Abstract])
  • PubMed: 0 records · searched September 2026"Rauwolscine"[Title/Abstract] AND ("dietary supplements"[MeSH] OR supplementation[Title/Abstract] OR supplement[Title/Abstract] OR supplements[Title/Abstract] OR "oral administration"[Title/Abstract]) AND (randomized controlled trial[pt] OR clinical trial[pt] OR meta-analysis[pt] OR systematic review[pt]) AND humans[MeSH]
  • PubMed: 1367 records · searched September 2026"Rauwolscine"[Title/Abstract]

This says what this database holds under these terms. It is not a finding that no research exists.

Context

Some pharmacological and animal research on rauwolscine's receptor activity exists, but well-controlled human dosing studies specific to rauwolscine could not be verified to a citable source here. A reviewer looking to upgrade this grade should look for human trials naming rauwolscine or alpha-yohimbine specifically, rather than yohimbine or general 'yohimbe bark extract' studies.

Insufficient dataToo little has been studied to say either way.

Rumors

  1. Rauwolscine boosts energy and focus.

    We haven’t found evidence strong enough to support this or rule it out.

    What was measured is not yet noted.

    Who’s saying this

    • Gorilla Mind, LLC — a brand: sells its own supplements and energy drinks
      How we know who this is
  2. Rauwolscine helps burn stubborn fat on the thighs and belly.

    We haven’t found evidence strong enough to support this or rule it out.

    What was measured is not yet noted.

    Who’s saying this

    • Gorilla Mind, LLC — a brand: sells its own supplements and energy drinks
      How we know who this is
  3. Rauwolscine suppresses appetite.

    We haven’t found evidence strong enough to support this or rule it out.

    What was measured is not yet noted.

    Who’s saying this

    • Gorilla Mind, LLC — a brand: sells its own supplements and energy drinks
      How we know who this is
  4. Supplements containing rauwolscine are possibly unsafe.

    We haven’t found evidence strong enough to support this or rule it out.

    What was measured is not yet noted.

    Who’s saying this

    • Operation Supplement Safety (OPSS) — a government body: Department of Defense dietary supplement and substance program for the military
      How we know who this is
      • “Operation Supplement Safety (OPSS) is the Department of Defense dietary supplement and substance program for the military” (their page)
  5. Rauwolscine increases fat loss.

    We haven’t found evidence strong enough to support this or rule it out.

    What was measured is not yet noted.

    Who’s saying this

    • Gorilla Mind, LLC — a brand: sells its own supplements and energy drinks
      How we know who this is