“Serine?”Here!L-serine
Hasn’t appeared in a scanned product yet.
As a supplement
Talk to your doctor or pharmacist.
Roll Call does not check drug interactions or assess personal safety.
Serine is a non-essential amino acid the body makes on its own and also obtains from protein-containing foods. It plays roles in building proteins and in the synthesis of other molecules used in the nervous system.
Why it’s used
Taken by some with interest in cognitive or nervous-system support, based largely on its biological role rather than established supplement outcomes.
What the evidence says
Human trials on supplemental L-serine are few and small, mostly exploratory studies in specific neurological conditions. There is no NIH ODS fact sheet on serine, and the evidence base is too limited to draw general conclusions about benefit from supplementation in healthy people.
Where we looked
There was no paper to cite here, so this is the search instead — run it yourself and see what we saw.
- PubMed: 22337 records · searched September 2026
"Serine"[Title/Abstract] AND (review[pt] OR "safety assessment"[Title/Abstract] OR "risk assessment"[Title/Abstract] OR toxicology[Title/Abstract] OR toxicity[Title/Abstract] OR characterization[Title/Abstract] OR characterisation[Title/Abstract]) - PubMed: 55 records · searched September 2026
"Serine"[Title/Abstract] AND ("dietary supplements"[MeSH] OR supplementation[Title/Abstract] OR supplement[Title/Abstract] OR supplements[Title/Abstract] OR "oral administration"[Title/Abstract]) AND (randomized controlled trial[pt] OR clinical trial[pt] OR meta-analysis[pt] OR systematic review[pt]) AND humans[MeSH] - PubMed: 126112 records · searched September 2026
"Serine"[Title/Abstract]
This says what this database holds under these terms. It is not a finding that no research exists.
Context
Where studied, small trials have used gram-level daily doses over periods of months, but sample sizes are small and results have not been broadly replicated.
Rumors
L-serine can halt, slow, or even reverse degenerative brain diseases such as ALS, Parkinson's and Alzheimer's.
Does not supporthealth and safety evidence
Studied in: ALS patients (phase I trial).
Measured as an outcome.
- L-Serine (NGO or audit) · Funding not checked
- Studies of Environmental Risk Factors in Amyotrophic Lateral Sclerosis (ALS) and a Phase I Clinical Trial of l-Serine (Peer-reviewed) · Funding not checked
- L-Serine, an Endogenous Amino Acid, Is a Potential Neuroprotective Agent for Neurological Disease and Injury (Peer-reviewed) · Funded by National Natural Science Foundation of China; Natural Science Foundation of Jiangsu Province; Nantong Science and Technology Project; Qing Lan Project of Jiangsu Province (government) · No conflicts declared
Who’s saying this
- iherb.com — we couldn’t open the site to see who runs it
Taking serine supplements increases the risk of developing Alzheimer's disease.
We haven’t found evidence strong enough to support this or rule it out.
What was measured is not yet noted.
Who’s saying this
- Sciencetimes.com — a publisher: science news and reference content
How we know who this is
- “Sciencetimes.com prides itself in providing a complete informational and content package for science enthusiasts in the web who aim to remain updated and well-informed regarding a wide array of topics of their interest.” (their page)
- “We are a source for original and timely science and research information as well as breaking news in the various fields we represent.” (their page)
- Sciencetimes.com — a publisher: science news and reference content
L-serine supplementation slows the progression of ALS (Lou Gehrig's disease).
Supports — suggestivehealth and safety evidence
Studied in: patients with ALS.
Measured as an outcome.
- Studies of Environmental Risk Factors in Amyotrophic Lateral Sclerosis (ALS) and a Phase I Clinical Trial of l-Serine (Peer-reviewed) · Funding not checked
- L-Serine (NGO or audit) · Funding not checked
Who’s saying this
- iherb.com — we couldn’t open the site to see who runs it
L-serine supplements support memory, focus and cognitive function.
Does not support — establishedhealth and safety evidence
Measured as a biomarker.
- L-Serine (NGO or audit) · Funding not checked
Who’s saying this
- BulkSupplements.com — a brand: sells nutritional supplement ingredients
How we know who this is
- “Located in Henderson, Nevada, BulkSupplements.com supplies over 500 pure nutritional supplement ingredients to hundreds of thousands of consumers and manufacturers.” (their page)
L-serine taken before bed improves sleep quality and reduces night-time awakenings.
Supports — suggestivehealth and safety evidence
Studied in: adults dissatisfied with their sleep.
Measured as an outcome.
- Effects of L-serine ingestion on human sleep (Peer-reviewed) · Funding not checked · No conflicts declared
Who’s saying this
- iherb.com — we couldn’t open the site to see who runs it