“Valine?”Here!

Varies by source

Hasn’t appeared in a scanned product yet.

As a supplement

Talk to your doctor or pharmacist.

Roll Call does not check drug interactions or assess personal safety.

An essential branched-chain amino acid (BCAA) obtained from dietary protein or supplied as an isolated supplement.

Why it’s used

Taken, often as part of a BCAA blend with leucine and isoleucine, to support muscle protein synthesis and recovery around exercise.

What the evidence says

Valine on its own has been studied far less than leucine, the BCAA most associated with muscle protein synthesis signaling. Most human evidence on BCAAs comes from combined-blend studies, making it hard to isolate valine's individual contribution; NIH's amino acid resources note this compound is essential but do not establish a specific supplemental benefit for it alone.

Context

Studies use BCAA blends rather than isolated valine, typically providing a few grams total per dose, so the individual role of valine at any specific amount has not been clearly established.

Rumors

1
Valine supplements can cause insomnia.
Sources cited — check not cleared.
Studied in: Veterans with traumatic brain injury.
Measured as an outcome.
- Dietary Supplementation With Branched Chain Amino Acids to Improve Sleep in Veterans With Traumatic Brain Injury: A Randomized Double-Blind Placebo-Controlled Pilot and Feasibility Trial (Peer-reviewed) · Funded by VA Portland Health Care System; VA Merit Review Award; National Center for Advancing Translational Sciences, National Institutes of Health; Portland VA Research Foundation; Oregon Medical Research Foundation (government) · No conflicts declared
Who’s saying this
- community.bulksupplements.com — the site doesn’t say who runs it
2
Valine boosts energy and reduces fatigue during workouts.
Not gradedhealth and safety evidence
Sources cited — no verdict reached.
What was measured is not yet noted.
- Combined Effect of Arginine, Valine, and Serine on Exercise-Induced Fatigue in Healthy Volunteers: A Randomized, Double-Blinded, Placebo-Controlled Crossover Study (Peer-reviewed) · Funded by Meiji Co., Ltd. (industry) · Authors declare a conflict of interest
Who’s saying this
- community.bulksupplements.com — the site doesn’t say who runs it
3
Valine supplements help muscles recover after intense exercise.
Not gradedhealth and safety evidence
Sources cited — no verdict reached.
What was measured is not yet noted.
- Attenuating Muscle Damage Biomarkers and Muscle Soreness After an Exercise-Induced Muscle Damage with Branched-Chain Amino Acid (BCAA) Supplementation: A Systematic Review and Meta-analysis with Meta-regression (Peer-reviewed) · Funding not clearly stated · No conflicts declared
- Does Branched-Chain Amino Acids (BCAAs) Supplementation Attenuate Muscle Damage Markers and Soreness after Resistance Exercise in Trained Males? A Meta-Analysis of Randomized Controlled Trials (Peer-reviewed) · Funded by University of Taipei; Ministry of Science and Technology (Taiwan) (government) · No conflicts declared
Who’s saying this
- BulkSupplements.com — a brand: sells nutritional supplement ingredients
  How we know who this is
  “Located in Henderson, Nevada, BulkSupplements.com supplies over 500 pure nutritional supplement ingredients to hundreds of thousands of consumers and manufacturers.” (their page)
4
Valine repairs and regenerates liver cells and supports liver health.
Does not supporthealth and safety evidence
Studied in: patients with liver cirrhosis/hepatic encephalopathy.
What was measured is not yet noted.
- Branched-chain amino acids supplementation has beneficial effects on the progression of liver cirrhosis: A meta-analysis (Peer-reviewed) · Funded by Key Research and Development Projects of Sichuan Science and Technology Department (government) · No conflicts declared
- Do branched-chain amino acids (BCAAs) help people with cirrhosis and hepatic encephalopathy (a brain disorder caused by severe liver disease)? (Peer-reviewed) · Funding not checked
Who’s saying this
- community.bulksupplements.com — the site doesn’t say who runs it
5
Taking too much valine causes headaches, fatigue, and loss of muscle coordination.
We haven’t found evidence strong enough to support this or rule it out.
What was measured is not yet noted.
Who’s saying this
- PureBulk — a brand: sells pure dietary supplement powders, oils and capsules
  How we know who this is
  “PureBulk was founded in 2008 by Timothy McNulty with a simple idea, that people can save money by buying the dietary supplements they want, without the fillers and additives.” (their page)
  “PureBulk offers a variety of over 250 pure dietary powders, oils and capsules as well as the tools necessary for you to accurately measure your supplements and make your own custom supplement blends and formulations using your own ingredients.” (their page)