“Vitamin B12?”Here!vitamin B12, cobalamin
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As a supplement
Talk to your doctor or pharmacist.
Roll Call does not check drug interactions or assess personal safety.
A water-soluble B vitamin required for nerve function, DNA synthesis, and red blood cell formation. Supplement forms include cyanocobalamin and methylcobalamin; this label does not specify which.
Why it’s used
Taken to maintain normal B12 status, particularly by people with reduced absorption (older adults, those on certain diets, or with digestive conditions affecting absorption) or low dietary intake.
What the evidence is for
correcting B12 deficiency and its symptoms.
What the evidence says
NIH ODS states that vitamin B12 is well established as essential, and that supplementation reliably corrects deficiency and reverses associated symptoms such as fatigue and nerve problems. Evidence for benefit in people who are not deficient is much thinner.
Dose studied
2.4–2.4 mcg — adult RDA, per NIH ODS.
Context
The adult RDA is 2.4 micrograms per day, higher during pregnancy and lactation, per NIH ODS. No tolerable upper intake level has been set because B12 has low toxicity from oral intake.
Rumors
Correcting vitamin B12 deficiency, which causes megaloblastic anemia, fatigue, a sore tongue, and numbness and tingling in the hands and feet that can become permanent if it is left untreated.
Supports — suggestivehealth and safety evidence
Studied in: adults with vitamin B12 deficiency.
Measured as a biomarker.
- Vitamin B12 Fact Sheet for Health Professionals (Regulatory) · Funding not checked
How much is a reference amount
- 2.4 mcg a dayfor adults 19 and over · Recommended Dietary Allowance
No upper limit has been set — the data was not sufficient to set one, which is a gap in the research rather than a finding about safety.
No UL, on grounds of low toxicity potential. The legacy corpus stored three different B12 ceilings across three rows, one of which (1000 mcg) exists nowhere in the DRI.
Every applicable line is shown because we don’t know which one is yours, and a reference intake is a target for a population, not a threshold for harm.