“Vitamin B3 (mixed)?”Here!Niacin
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As a supplement
Talk to your doctor or pharmacist.
Roll Call does not check drug interactions or assess personal safety.
Vitamin B3, supplied here as a mix of its chemical forms — commonly niacin (nicotinic acid) and niacinamide (nicotinamide) — an essential nutrient involved in energy metabolism.
Why it’s used
Taken to maintain adequate niacin status, which supports normal metabolism, skin, nervous system, and digestive function, and to prevent deficiency.
What the evidence is for
preventing niacin deficiency (pellagra) and meeting normal metabolic needs.
What the evidence says
NIH ODS documents niacin as essential, with deficiency causing pellagra; adequate intake prevents this. Separately, high pharmacologic doses of nicotinic acid (well above typical supplement or dietary amounts) have been studied for altering blood lipid levels, but this is a distinct use from ordinary vitamin supplementation and carries its own considerations not implied by a standard multivitamin-level dose.
Dose studied
14–35 mg — adult RDA up to the tolerable upper intake level, per NIH ODS.
Context
Lipid-related research uses doses far higher than the amounts found in typical dietary supplements or the RDA; general supplement-level intake is studied mainly in the context of meeting nutritional needs, not lipid management.
Rumors
Preventing and correcting the pellagra of niacin deficiency — a rash on sun-exposed skin, vomiting and diarrhea, and depression and memory loss that can end in death.
Supports — establishedhealth and safety evidence
Measured as an outcome.
- Niacin — Health Professional Fact Sheet (Regulatory) · Funding not checked
How much is a reference amount
- 14 mg NE a dayfor adults 19 and over, women · Recommended Dietary Allowance
Upper limit 35 mg a day, from supplements only — it does not apply to the same nutrient in food.
- 16 mg NE a dayfor adults 19 and over, men · Recommended Dietary Allowance
Upper limit 35 mg a day, from supplements only — it does not apply to the same nutrient in food.
The RDA is in niacin equivalents (1 NE = 1 mg niacin or 60 mg tryptophan); the UL is in mg and applies only to supplemental niacin, not to niacin from food.
Every applicable line is shown because we don’t know which one is yours, and a reference intake is a target for a population, not a threshold for harm.