Roll Call

“Vitamin B6 (pyridoxal 5-phosphate)?”Here!vitamin B6, active P5P form

Synthetic

Hasn’t appeared in a scanned product yet.

As a supplement

Talk to your doctor or pharmacist.

Roll Call does not check drug interactions or assess personal safety.

The biologically active coenzyme form of vitamin B6, used directly by the body without needing further conversion, unlike the more common pyridoxine hydrochloride form.

Why it’s used

Taken to maintain normal vitamin B6 status, which supports amino acid metabolism, neurotransmitter synthesis, and red blood cell formation.

What the evidence is for

correcting vitamin B6 deficiency.

What the evidence says

NIH ODS confirms vitamin B6 is essential and that supplementation corrects deficiency, which can cause symptoms such as anemia and nerve problems. Evidence specifically comparing the P5P form to other forms in terms of clinical outcomes is limited; most established evidence concerns vitamin B6 status generally rather than this form in particular.

Dose studied

1.3–100 mg — adult RDA up to the tolerable upper intake level, per NIH ODS.

Context

The adult RDA for vitamin B6 is 1.3 to 1.7 milligrams per day depending on age and sex, with a tolerable upper intake level of 100 milligrams per day for adults, per NIH ODS.

Rumors

  1. Correcting vitamin B6 deficiency, which causes microcytic anemia, cracked lips and a swollen tongue, dermatitis, depression and confusion, and seizures in infants.

    Supports — establishedhealth and safety evidence

    Studied in: patients with rheumatoid arthritis.

    Measured as a biomarker.

How much is a reference amount

  • 1.3 mg a dayfor adults 19–50 · Recommended Dietary Allowance

    Upper limit 100 mg a day, from food and supplements together.

  • 1.5 mg a dayfor adults 51–70, women · Recommended Dietary Allowance

    Upper limit 100 mg a day, from food and supplements together.

  • 1.7 mg a dayfor adults 51–70, men · Recommended Dietary Allowance

    Upper limit 100 mg a day, from food and supplements together.

  • 1.5 mg a dayfor adults 71 and over, women · Recommended Dietary Allowance

    Upper limit 100 mg a day, from food and supplements together.

  • 1.7 mg a dayfor adults 71 and over, men · Recommended Dietary Allowance

    Upper limit 100 mg a day, from food and supplements together.

The worksheet planned one adults_19_plus row for B6. The DRI is age-differentiated: it rises at 51, and it differentiates by sex only from 51 onwards. Five rows, not one.

Every applicable line is shown because we don’t know which one is yours, and a reference intake is a target for a population, not a threshold for harm.