Roll Call

“Vitamin B6 (pyridoxal 5 phosphate)?”Here!active vitamin B6 (PLP)

Synthetic

Hasn’t appeared in a scanned product yet.

As a supplement

Talk to your doctor or pharmacist.

Roll Call does not check drug interactions or assess personal safety.

Pyridoxal 5'-phosphate is the metabolically active coenzyme form of vitamin B6, the form the body ultimately converts other B6 forms into for use in enzyme reactions.

Why it’s used

Taken as a source of vitamin B6, which the body needs for amino acid metabolism, red blood cell formation, and nervous system function.

What the evidence is for

preventing vitamin B6 deficiency and supporting normal amino acid and red blood cell metabolism.

What the evidence says

NIH ODS confirms vitamin B6's established role in these processes and documents deficiency effects such as anemia and dermatitis. Evidence for benefits from supplementation above the RDA in people who are not deficient, such as for mood or cognitive claims, is limited and inconsistent. PLP is not shown to outperform other B6 forms once absorbed.

Dose studied

1.3–100 mg — adult RDA up to the tolerable upper intake level, per NIH ODS.

Context

NIH ODS lists an adult RDA of about 1.3-2.0 mg/day depending on age and sex, and a tolerable upper intake level of 100 mg/day; high-dose studies exploring neuropathy risk have used intakes well above typical dietary levels.

Rumors

  1. Correcting vitamin B6 deficiency, which causes microcytic anemia, cracked lips and a swollen tongue, dermatitis, depression and confusion, and seizures in infants.

    Supports — establishedhealth and safety evidence

    Measured as a biomarker.

How much is a reference amount

  • 1.3 mg a dayfor adults 19–50 · Recommended Dietary Allowance

    Upper limit 100 mg a day, from food and supplements together.

  • 1.5 mg a dayfor adults 51–70, women · Recommended Dietary Allowance

    Upper limit 100 mg a day, from food and supplements together.

  • 1.7 mg a dayfor adults 51–70, men · Recommended Dietary Allowance

    Upper limit 100 mg a day, from food and supplements together.

  • 1.5 mg a dayfor adults 71 and over, women · Recommended Dietary Allowance

    Upper limit 100 mg a day, from food and supplements together.

  • 1.7 mg a dayfor adults 71 and over, men · Recommended Dietary Allowance

    Upper limit 100 mg a day, from food and supplements together.

The worksheet planned one adults_19_plus row for B6. The DRI is age-differentiated: it rises at 51, and it differentiates by sex only from 51 onwards. Five rows, not one.

Every applicable line is shown because we don’t know which one is yours, and a reference intake is a target for a population, not a threshold for harm.