“Vitamin B6 (pyridoxine 5-phosphate)?”Here!vitamin B6 (as pyridoxal 5'-phosphate)
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As a supplement
Talk to your doctor or pharmacist.
Roll Call does not check drug interactions or assess personal safety.
A water-soluble B vitamin involved in amino acid and neurotransmitter metabolism. This form supplies vitamin B6 as pyridoxal 5'-phosphate, the vitamin's active coenzyme form in the body.
Why it’s used
Taken to meet dietary vitamin B6 requirements, and sometimes for mood, PMS-related symptoms, or nerve support.
What the evidence is for
correcting vitamin B6 deficiency.
What the evidence says
NIH ODS confirms vitamin B6's essential role and that supplementation corrects deficiency. Evidence for benefits beyond correcting deficiency, such as for mood or premenstrual symptoms, is more limited and mixed. Very high, prolonged intakes have been associated with nerve-related symptoms in case reports.
Dose studied
1.3–100 mg — adult RDA up to the tolerable upper intake level, per NIH ODS.
Context
Deficiency-correction doses sit near the RDA; the tolerable upper intake level reflects concern about high-dose, long-term use rather than typical supplement dosing.
Rumors
Correcting vitamin B6 deficiency, which causes microcytic anemia, cracked lips and a swollen tongue, dermatitis, depression and confusion, and seizures in infants.
Supports — establishedhealth and safety evidence
Studied in: patients with rheumatoid arthritis (low vitamin B6 status).
Measured as a biomarker.
- Vitamin B6 Fact Sheet for Health Professionals (Regulatory) · Funding not checked
How much is a reference amount
- 1.3 mg a dayfor adults 19–50 · Recommended Dietary Allowance
Upper limit 100 mg a day, from food and supplements together.
- 1.5 mg a dayfor adults 51–70, women · Recommended Dietary Allowance
Upper limit 100 mg a day, from food and supplements together.
- 1.7 mg a dayfor adults 51–70, men · Recommended Dietary Allowance
Upper limit 100 mg a day, from food and supplements together.
- 1.5 mg a dayfor adults 71 and over, women · Recommended Dietary Allowance
Upper limit 100 mg a day, from food and supplements together.
- 1.7 mg a dayfor adults 71 and over, men · Recommended Dietary Allowance
Upper limit 100 mg a day, from food and supplements together.
The worksheet planned one adults_19_plus row for B6. The DRI is age-differentiated: it rises at 51, and it differentiates by sex only from 51 onwards. Five rows, not one.
Every applicable line is shown because we don’t know which one is yours, and a reference intake is a target for a population, not a threshold for harm.