“Vitamin E (alpha-tocopheryl succinate)?”Here!vitamin E
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As a supplement
Talk to your doctor or pharmacist.
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A fat-soluble vitamin and antioxidant. Alpha-tocopheryl succinate is a stabilized ester form of alpha-tocopherol, the type of vitamin E the body uses most readily, converted back to the active form after absorption.
Why it’s used
Taken to meet vitamin E requirements and, more often, in the hope that its antioxidant activity supports general health or protects against age-related and cardiovascular conditions.
What the evidence is for
correcting vitamin E deficiency.
What the evidence says
NIH ODS confirms vitamin E is essential and that supplementation corrects deficiency, which is rare in developed countries. Large trials looking at whether extra vitamin E prevents heart disease or cancer in people who are not deficient have generally found no benefit, and some found a higher risk of certain outcomes at high doses.
Dose studied
15–1000 mg — adult RDA up to the tolerable upper intake level, per NIH ODS.
Context
Deficiency-correction studies use amounts near the RDA; disease-prevention trials tested doses well above typical dietary intake and did not show the hoped-for benefit.
Rumors
Correcting vitamin E deficiency, which causes nerve damage in the hands and feet, unsteady movement, muscle weakness and damage to the retina.
Supports — establishedhealth and safety evidence
Studied in: people with rare genetic disorders causing vitamin E deficiency (AVED, abetalipoproteinemia) or fat-malabsorption conditions.
Measured as an outcome.
- Vitamin E - Health Professional Fact Sheet (Regulatory) · Funding not checked
How much is a reference amount
- 15 mg a dayfor adults 19 and over · Recommended Dietary Allowance
Upper limit 1,000 mg a day, from supplements only — it does not apply to the same nutrient in food and only to alpha-tocopherol — not to gamma-tocopherol or the tocotrienols.
Both figures are alpha-tocopherol. The UL applies to supplemental alpha-tocopherol in any form, including the eight stereoisomers of the synthetic (dl-) material.
Every applicable line is shown because we don’t know which one is yours, and a reference intake is a target for a population, not a threshold for harm.