“Allantoin?”Here!
Appears in 1 scanned product.
In personal care
A compound found naturally in comfrey root and also made synthetically for cosmetic use. It is a small, water-soluble molecule known for calming and softening effects on skin.
Why it’s used
Formulators add it to soothe irritation, support the skin's barrier, and help with mild exfoliation by softening the outer layer of skin cells. It is common in products aimed at sensitive or compromised skin.
What the evidence says
The CIR Expert Panel's safety assessment concluded that available test data were sufficient to support the safety of allantoin and its related complexes at the concentrations used in cosmetics, with allantoin itself used up to 2% in over 1,300 products. The abstract does not describe specific adverse findings or mechanisms of concern. It notes data gaps for two minor allantoin complexes (galacturonic acid and polygalacturonic acid), but these do not apply to allantoin itself.
Context
Used across rinse-off and leave-on products alike, generally at low concentrations (0.1–2%) where its main role is calming rather than active treatment.
Rumors
Allantoin moisturizes skin by increasing its water content.
Not gradedsourcing and supply-chain evidence
Sources cited — no verdict reached.
What was measured is not yet noted.
- Skin Protectant Drug Products for Over-the-Counter Human Use; Final Monograph (Regulatory) · Funding not checked
Who’s saying this
- 100% PURE — a brand: makes and sells its own clean skincare and makeup
How we know who this is
- “We chose not to sell because 100% PURE is more than a company to us.” (their page)
- “Everything we make is formulated and manufactured in our own Silicon Valley, California facility, powered entirely by solar energy.” (their page)
Allantoin in shampoo fights dandruff and soothes scalp conditions.
Sources cited — check not cleared.
Measured as an outcome.
- 21 CFR 310.545 -- Drug products containing certain active ingredients offered over-the-counter (OTC) for certain uses. (Regulatory) · Funding not checked
Who’s saying this
- naturallycurly.com — we couldn’t open the site to see who runs it
Allantoin heals wounds and reduces scarring.
Sources cited — check not cleared.
Measured as an outcome.
- Efficacy and tolerability of the investigational topical cream SD-101 (6% allantoin) in patients with epidermolysis bullosa: a phase 3, randomized, double-blind, vehicle-controlled trial (ESSENCE study) (Peer-reviewed) · Funded by Amicus Therapeutics, Inc. (industry) · Authors declare a conflict of interest
- Skin Protectant Drug Products for Over-the-Counter Human Use; Final Monograph (Regulatory) · Funding not checked
- Profile of wound healing process induced by allantoin (Peer-reviewed) · Funded by FAPEMIG (government) · No conflicts declared
Who’s saying this
- 100% PURE — a brand: makes and sells its own clean skincare and makeup
How we know who this is
- “We chose not to sell because 100% PURE is more than a company to us.” (their page)
- “Everything we make is formulated and manufactured in our own Silicon Valley, California facility, powered entirely by solar energy.” (their page)
Allantoin exfoliates skin by speeding up the shedding of dead skin cells.
We haven’t found evidence strong enough to support this or rule it out.
What was measured is not yet noted.
Who’s saying this
- 100% PURE — a brand: makes and sells its own clean skincare and makeup
How we know who this is
- “We chose not to sell because 100% PURE is more than a company to us.” (their page)
- “Everything we make is formulated and manufactured in our own Silicon Valley, California facility, powered entirely by solar energy.” (their page)
- 100% PURE — a brand: makes and sells its own clean skincare and makeup
Allantoin soothes and calms skin, reducing redness and irritation.
Not gradedhealth and safety evidence
Sources cited — no verdict reached.
What was measured is not yet noted.
- Efficacy and tolerability of the investigational topical cream SD-101 (6% allantoin) in patients with epidermolysis bullosa: a phase 3, randomized, double-blind, vehicle-controlled trial (ESSENCE study) (Peer-reviewed) · Funded by Amicus Therapeutics, Inc. (industry) · Authors declare a conflict of interest
- Profile of wound healing process induced by allantoin (Peer-reviewed) · Funded by FAPEMIG (government) · No conflicts declared
Who’s saying this
- Curology — a brand: sells personalized prescription skincare
How we know who this is
- “Founded by Dr. David Lortscher in 2014, Curology has led the way in making personalized skincare accessible in all 50 states.” (their page)