“Histidine?”Here!
Appears in 2 scanned products.
In personal care
An amino acid, one of the essential building blocks of proteins in the human body, also found naturally in skin and hair.
Why it’s used
Used as a skin- and hair-conditioning agent, and sometimes as an antioxidant helper, drawing on its natural role in the body's own protein and pH-buffering systems.
What the evidence says
The Cosmetic Ingredient Review panel evaluated α-amino acids, including histidine, as used in cosmetics and concluded they are safe as used based on dermal irritation and sensitization data. The review focused on topical, cosmetic-concentration exposure rather than occupational or industrial exposure. The abstract does not provide dose-by-dose detail or describe any adverse findings.
Context
Used at low concentrations in both rinse-off and leave-on products as a minor conditioning or functional ingredient.
Rumors
Histidine is an antioxidant that soothes skin.
We haven’t found evidence strong enough to support this or rule it out.
What was measured is not yet noted.
Who’s saying this
- Paula's Choice — a brand: sells its own skincare products
How we know who this is
- “Copyright © Paula's Choice” (their page)
- “Paula's Choice | Research-First Skincare Products” (their page)
- Paula's Choice — a brand: sells its own skincare products
Histidine hydrates skin and supports the skin barrier.
Not gradedhealth and safety evidence
Sources cited — no verdict reached.
What was measured is not yet noted.
- Feeding filaggrin: effects of l-histidine supplementation in atopic dermatitis (Peer-reviewed) · Funded by Scottish Overseas Research Student Award; University of Edinburgh College of Medicine and Veterinary Medicine PhD Scholarship; University of Manchester · Authors declare a conflict of interest
Who’s saying this
- skinsort.com — we couldn’t open the site to see who runs it
Histidine reduces static and frizz in hair.
We haven’t found evidence strong enough to support this or rule it out.
What was measured is not yet noted.
Who’s saying this
- glooshi.com — we couldn’t open the site to see who runs it
Histidine helps atopic dermatitis (eczema) and scalp irritation.
Not gradedhealth and safety evidence
Sources cited — no verdict reached.
What was measured is not yet noted.
- Feeding filaggrin: effects of l-histidine supplementation in atopic dermatitis (Peer-reviewed) · Funded by Scottish Overseas Research Student Award; University of Edinburgh College of Medicine and Veterinary Medicine PhD Scholarship; University of Manchester · Authors declare a conflict of interest
- Histidine in Health and Disease: Metabolism, Physiological Importance, and Use as a Supplement (Peer-reviewed) · Funded by Charles University (program PROGRES Q40/02) · No conflicts declared
Who’s saying this
- Divi — a brand: sells scalp and hair care products
How we know who this is
- “Divi partners with and educates stylists all across the country to bring quality scalp care to your local salon.” (their page)
Histidine in shampoo and scalp serum helps prevent hair loss and promotes hair growth.
We haven’t found evidence strong enough to support this or rule it out.
What was measured is not yet noted.
Who’s saying this
- Divi — a brand: sells scalp and hair care products
How we know who this is
- “Divi partners with and educates stylists all across the country to bring quality scalp care to your local salon.” (their page)
- Divi — a brand: sells scalp and hair care products
As a supplement
Talk to your doctor or pharmacist.
Roll Call does not check drug interactions or assess personal safety.
An essential amino acid, meaning the body cannot make enough of it on its own and must obtain it from food or supplements. It is a component of proteins throughout the body and a precursor to histamine.
Why it’s used
Taken as a general amino acid building block, sometimes marketed toward protein synthesis or as part of amino acid blends.
What the evidence says
Histidine's role as an essential dietary amino acid is well established nutritionally, but evidence for benefits from isolated histidine supplementation beyond meeting basic dietary need is limited and not well studied in controlled trials.
Where we looked
There was no paper to cite here, so this is the search instead — run it yourself and see what we saw.
- PubMed: 6984 records · searched September 2026
"Histidine"[Title/Abstract] AND (review[pt] OR "safety assessment"[Title/Abstract] OR "risk assessment"[Title/Abstract] OR toxicology[Title/Abstract] OR toxicity[Title/Abstract] OR characterization[Title/Abstract] OR characterisation[Title/Abstract]) - PubMed: 70 records · searched September 2026
"Histidine"[Title/Abstract] AND ("dietary supplements"[MeSH] OR supplementation[Title/Abstract] OR supplement[Title/Abstract] OR supplements[Title/Abstract] OR "oral administration"[Title/Abstract]) AND (randomized controlled trial[pt] OR clinical trial[pt] OR meta-analysis[pt] OR systematic review[pt]) AND humans[MeSH] - PubMed: 49950 records · searched September 2026
"Histidine"[Title/Abstract]
This says what this database holds under these terms. It is not a finding that no research exists.
Context
Most research on histidine intake concerns overall dietary adequacy rather than supplementation above typical dietary levels for a specific health outcome.
Rumors
Taking L-histidine reduces the severity of eczema (atopic dermatitis).
We haven’t found evidence strong enough to support this or rule it out.
What was measured is not yet noted.
Who’s saying this
- Codex Labs — a brand: sells skincare and supplements for eczema and acne
How we know who this is
- “Codex Labs is grounded in science, focused on the microbiome, and pioneering clinically proven, inside out solutions for eczema and acne.” (their page)
- Codex Labs — a brand: sells skincare and supplements for eczema and acne
Where it shows up
and 1 more product