Histidine
Appears in 2 scanned products.
An amino acid, one of the essential building blocks of proteins in the human body, also found naturally in skin and hair.
Why it’s used
Used as a skin- and hair-conditioning agent, and sometimes as an antioxidant helper, drawing on its natural role in the body's own protein and pH-buffering systems.
What the evidence says
There is no significant body of cosmetic-specific safety literature raising concern, consistent with its status as a normal dietary and bodily amino acid; the CIR has reviewed related amino acids as a class and found them generally safe as used.
Context
Used at low concentrations in both rinse-off and leave-on products as a minor conditioning or functional ingredient.
As a supplement
Talk to your doctor or pharmacist.
Roll Call does not check drug interactions or assess personal safety.
An essential amino acid, meaning the body cannot make enough of it on its own and must obtain it from food or supplements. It is a component of proteins throughout the body and a precursor to histamine.
Why it’s used
Taken as a general amino acid building block, sometimes marketed toward protein synthesis or as part of amino acid blends.
What the evidence says
Histidine's role as an essential dietary amino acid is well established nutritionally, but evidence for benefits from isolated histidine supplementation beyond meeting basic dietary need is limited and not well studied in controlled trials.
Where we looked
There was no paper to cite here, so this is the search instead — run it yourself and see what we saw.
- PubMed: 70 records · searched August 2026
"Histidine"[Title/Abstract] AND ("dietary supplements"[MeSH] OR supplementation[Title/Abstract] OR supplement[Title/Abstract] OR supplements[Title/Abstract] OR "oral administration"[Title/Abstract]) AND (randomized controlled trial[pt] OR clinical trial[pt] OR meta-analysis[pt] OR systematic review[pt]) AND humans[MeSH] - PubMed: 49765 records · searched August 2026
"Histidine"[Title/Abstract]
This says what this database holds under these terms. It is not a finding that no research exists.
Context
Most research on histidine intake concerns overall dietary adequacy rather than supplementation above typical dietary levels for a specific health outcome.
Educational information, not medical or safety advice. Consult a professional for allergies or medical concerns.